Unique behavior of Trypanosoma cruzi mevalonate kinase: A conserved glycosomal enzyme involved in host cell invasion and signaling

Mevalonate kinase (MVK) is an essential enzyme acting in early steps of sterol isoprenoids biosynthesis, such as cholesterol in humans or ergosterol in trypanosomatids. MVK is conserved from bacteria to mammals, and localizes to glycosomes in trypanosomatids. During the course of T. cruzi MVK charac...

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Detalles Bibliográficos
Autores principales: Ferreira, Éden Ramalho, Horjales, Eduardo, Bonfim-Melo, Alexis, Cortez, Cristian, da Silva, Claudio Vieira, De Groote, Michel, Sobreira, Tiago José Paschoal, Cruz, Mário Costa, Lima, Fabio Mitsuo, Cordero, Esteban Mauricio, Yoshida, Nobuko, da Silveira, José Franco, Mortara, Renato Arruda, Bahia, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845012/
https://www.ncbi.nlm.nih.gov/pubmed/27113535
http://dx.doi.org/10.1038/srep24610

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