ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways

Endosomal sorting required for transport (ESCRT) complexes orchestrate endo-lysosomal sorting of ubiquitinated proteins, multivesicular body formation and autophagic degradation. Defects in the ESCRT pathway have been implicated in many neurodegenerative diseases, but the underlying molecular mechan...

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Detalles Bibliográficos
Autores principales: Oshima, Ryuji, Hasegawa, Takafumi, Tamai, Keiichi, Sugeno, Naoto, Yoshida, Shun, Kobayashi, Junpei, Kikuchi, Akio, Baba, Toru, Futatsugi, Akira, Sato, Ikuro, Satoh, Kennichi, Takeda, Atsushi, Aoki, Masashi, Tanaka, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845015/
https://www.ncbi.nlm.nih.gov/pubmed/27112194
http://dx.doi.org/10.1038/srep24997

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