Emerging roles of ATF3 in the suppression of prostate cancer

Stress response mediator activating transcription factor 3 (ATF3) engages in diverse oncogenic pathways including the androgen receptor signaling essential for prostatic proliferation. In line with frequent downregulation of ATF3 expression in human prostate cancers, we have provided the first genet...

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Detalles Bibliográficos
Autores principales: Wang, Ziyan, Yan, Chunhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845162/
https://www.ncbi.nlm.nih.gov/pubmed/27308526
http://dx.doi.org/10.1080/23723556.2015.1010948
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author Wang, Ziyan
Yan, Chunhong
author_facet Wang, Ziyan
Yan, Chunhong
author_sort Wang, Ziyan
collection PubMed
description Stress response mediator activating transcription factor 3 (ATF3) engages in diverse oncogenic pathways including the androgen receptor signaling essential for prostatic proliferation. In line with frequent downregulation of ATF3 expression in human prostate cancers, we have provided the first genetic evidence supporting the role of ATF3 as a tumor suppressor in a subset of prostate cancers with PTEN dysfunction.
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spelling pubmed-48451622016-06-15 Emerging roles of ATF3 in the suppression of prostate cancer Wang, Ziyan Yan, Chunhong Mol Cell Oncol Author's View Stress response mediator activating transcription factor 3 (ATF3) engages in diverse oncogenic pathways including the androgen receptor signaling essential for prostatic proliferation. In line with frequent downregulation of ATF3 expression in human prostate cancers, we have provided the first genetic evidence supporting the role of ATF3 as a tumor suppressor in a subset of prostate cancers with PTEN dysfunction. Taylor & Francis 2015-02-03 /pmc/articles/PMC4845162/ /pubmed/27308526 http://dx.doi.org/10.1080/23723556.2015.1010948 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Wang, Ziyan
Yan, Chunhong
Emerging roles of ATF3 in the suppression of prostate cancer
title Emerging roles of ATF3 in the suppression of prostate cancer
title_full Emerging roles of ATF3 in the suppression of prostate cancer
title_fullStr Emerging roles of ATF3 in the suppression of prostate cancer
title_full_unstemmed Emerging roles of ATF3 in the suppression of prostate cancer
title_short Emerging roles of ATF3 in the suppression of prostate cancer
title_sort emerging roles of atf3 in the suppression of prostate cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845162/
https://www.ncbi.nlm.nih.gov/pubmed/27308526
http://dx.doi.org/10.1080/23723556.2015.1010948
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