Chemical parsing: Dissecting cell dependencies with a toolkit of selective BCL-2 family inhibitors

The BCL-2/BCL-X(L) inhibitor navitoclax has shown promise for the treatment of cancer but on-target toxicities have limited its utility. Recently, the generation of selective BCL-2 family inhibitors has enabled a careful dissection of BCL-2 biology, and early work indicates that these molecules have...

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Detalles Bibliográficos
Autor principal: Leverson, Joel D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845185/
https://www.ncbi.nlm.nih.gov/pubmed/27308564
http://dx.doi.org/10.1080/23723556.2015.1050155
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author Leverson, Joel D.
author_facet Leverson, Joel D.
author_sort Leverson, Joel D.
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description The BCL-2/BCL-X(L) inhibitor navitoclax has shown promise for the treatment of cancer but on-target toxicities have limited its utility. Recently, the generation of selective BCL-2 family inhibitors has enabled a careful dissection of BCL-2 biology, and early work indicates that these molecules have improved therapeutic profiles for the treatment of cancer.
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spelling pubmed-48451852016-06-15 Chemical parsing: Dissecting cell dependencies with a toolkit of selective BCL-2 family inhibitors Leverson, Joel D. Mol Cell Oncol Author's View The BCL-2/BCL-X(L) inhibitor navitoclax has shown promise for the treatment of cancer but on-target toxicities have limited its utility. Recently, the generation of selective BCL-2 family inhibitors has enabled a careful dissection of BCL-2 biology, and early work indicates that these molecules have improved therapeutic profiles for the treatment of cancer. Taylor & Francis 2015-05-26 /pmc/articles/PMC4845185/ /pubmed/27308564 http://dx.doi.org/10.1080/23723556.2015.1050155 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Leverson, Joel D.
Chemical parsing: Dissecting cell dependencies with a toolkit of selective BCL-2 family inhibitors
title Chemical parsing: Dissecting cell dependencies with a toolkit of selective BCL-2 family inhibitors
title_full Chemical parsing: Dissecting cell dependencies with a toolkit of selective BCL-2 family inhibitors
title_fullStr Chemical parsing: Dissecting cell dependencies with a toolkit of selective BCL-2 family inhibitors
title_full_unstemmed Chemical parsing: Dissecting cell dependencies with a toolkit of selective BCL-2 family inhibitors
title_short Chemical parsing: Dissecting cell dependencies with a toolkit of selective BCL-2 family inhibitors
title_sort chemical parsing: dissecting cell dependencies with a toolkit of selective bcl-2 family inhibitors
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845185/
https://www.ncbi.nlm.nih.gov/pubmed/27308564
http://dx.doi.org/10.1080/23723556.2015.1050155
work_keys_str_mv AT leversonjoeld chemicalparsingdissectingcelldependencieswithatoolkitofselectivebcl2familyinhibitors

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