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Chemical parsing: Dissecting cell dependencies with a toolkit of selective BCL-2 family inhibitors
The BCL-2/BCL-X(L) inhibitor navitoclax has shown promise for the treatment of cancer but on-target toxicities have limited its utility. Recently, the generation of selective BCL-2 family inhibitors has enabled a careful dissection of BCL-2 biology, and early work indicates that these molecules have...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845185/ https://www.ncbi.nlm.nih.gov/pubmed/27308564 http://dx.doi.org/10.1080/23723556.2015.1050155 |