Sustaining the spindle assembly checkpoint to improve cancer therapy

To prevent chromosome segregation errors, the spindle assembly checkpoint (SAC) delays mitosis exit until proper spindle assembly. We found that the FCP1 phosphatase and its downstream target WEE1 kinase oppose the SAC, promoting mitosis exit despite malformed spindles. We further showed that target...

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Detalles Bibliográficos
Autores principales: Visconti, Roberta, Della Monica, Rosa, Grieco, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845201/
https://www.ncbi.nlm.nih.gov/pubmed/27308561
http://dx.doi.org/10.1080/23723556.2015.1046583
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author Visconti, Roberta
Della Monica, Rosa
Grieco, Domenico
author_facet Visconti, Roberta
Della Monica, Rosa
Grieco, Domenico
author_sort Visconti, Roberta
collection PubMed
description To prevent chromosome segregation errors, the spindle assembly checkpoint (SAC) delays mitosis exit until proper spindle assembly. We found that the FCP1 phosphatase and its downstream target WEE1 kinase oppose the SAC, promoting mitosis exit despite malformed spindles. We further showed that targeting this pathway might be useful for cancer therapy.
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spelling pubmed-48452012016-06-26 Sustaining the spindle assembly checkpoint to improve cancer therapy Visconti, Roberta Della Monica, Rosa Grieco, Domenico Mol Cell Oncol Author's View To prevent chromosome segregation errors, the spindle assembly checkpoint (SAC) delays mitosis exit until proper spindle assembly. We found that the FCP1 phosphatase and its downstream target WEE1 kinase oppose the SAC, promoting mitosis exit despite malformed spindles. We further showed that targeting this pathway might be useful for cancer therapy. Taylor & Francis 2015-06-26 /pmc/articles/PMC4845201/ /pubmed/27308561 http://dx.doi.org/10.1080/23723556.2015.1046583 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Visconti, Roberta
Della Monica, Rosa
Grieco, Domenico
Sustaining the spindle assembly checkpoint to improve cancer therapy
title Sustaining the spindle assembly checkpoint to improve cancer therapy
title_full Sustaining the spindle assembly checkpoint to improve cancer therapy
title_fullStr Sustaining the spindle assembly checkpoint to improve cancer therapy
title_full_unstemmed Sustaining the spindle assembly checkpoint to improve cancer therapy
title_short Sustaining the spindle assembly checkpoint to improve cancer therapy
title_sort sustaining the spindle assembly checkpoint to improve cancer therapy
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845201/
https://www.ncbi.nlm.nih.gov/pubmed/27308561
http://dx.doi.org/10.1080/23723556.2015.1046583
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