Cargando…

New strategies to maximize therapeutic opportunities for NAMPT inhibitors in oncology

Nicotinamide phosphoribosyltransferase (NAMPT) is crucial for nicotinamide adenine dinucleotide (NAD(+)) biosynthesis in mammalian cells. NAMPT inhibitors represent multifunctional anticancer agents that act on NAD(+) metabolism to shut down glycolysis, nucleotide biosynthesis, and ATP generation an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Roulston, Anne, Shore, Gordon C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2015
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845202/ https://www.ncbi.nlm.nih.gov/pubmed/27308565 http://dx.doi.org/10.1080/23723556.2015.1052180

Ejemplares similares

Novel NAPRT specific antibody identifies small cell lung cancer and neuronal cancers as promising clinical indications for a NAMPT inhibitor/niacin co-administration strategy
por: Cole, Jonathan, et al.
Publicado: (2017)

Targeting NAMPT as a therapeutic strategy against stroke
por: Wang, Shu-Na, et al.
Publicado: (2019)

Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy
por: Galli, Ubaldina, et al.
Publicado: (2020)

Updated Functional Roles of NAMPT in Carcinogenesis and Therapeutic Niches
por: Lin, Tsung-Chieh
Publicado: (2022)

Linkage of NAMPT promoter variants to eNAMPT secretion, plasma eNAMPT levels, and ARDS severity
por: Lynn, Heather, et al.
Publicado: (2023)

Review of various NAMPT inhibitors for the treatment of cancer
por: Wei, Yichen, et al.
Publicado: (2022)

Discovery of Novel Inhibitors and Fluorescent Probe Targeting NAMPT
por: Wang, Xia, et al.
Publicado: (2015)

Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors
por: Wang, Weiru, et al.
Publicado: (2014)

Drug repositioning strategy for the identification of novel telomere‐damaging agents: A role for NAMPT inhibitors
por: Rizzo, Angela, et al.
Publicado: (2023)

Visfatin/Nampt: An Adipokine with Cardiovascular Impact
por: Romacho, Tania, et al.
Publicado: (2013)

NAMPT: A potential prognostic and therapeutic biomarker in patients with glioblastoma
por: Guo, Qiuyun, et al.
Publicado: (2019)

HGG-33. EXPLOITING METABOLIC DEFECTS WITH NAMPT INHIBITORS IN DIPG
por: Muraleedharan, Ranjithmenon, et al.
Publicado: (2021)

NAD/NAMPT and mTOR Pathways in Melanoma: Drivers of Drug Resistance and Prospective Therapeutic Targets
por: Indini, Alice, et al.
Publicado: (2022)

Visfatin/PBEF/Nampt: A New Cardiovascular Target?
por: Peiró, Concepción, et al.
Publicado: (2010)

Opportunities to maximize value with integrated palliative care
por: Bergman, Jonathan, et al.
Publicado: (2016)

Potential Therapeutic Effects of NAMPT-Mediated NAD Biosynthesis in Depression In Vivo
por: Wang, Jue, et al.
Publicado: (2022)

The NAMPT inhibitor FK866 reverts the damage in spinal cord injury
por: Esposito, Emanuela, et al.
Publicado: (2012)

Osteoimmuno-Oncology: Therapeutic Opportunities for Targeting Immune Cells in Bone Metastasis
por: Kähkönen, Tiina E., et al.
Publicado: (2021)

Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer
por: Espindola-Netto, Jair Machado, et al.
Publicado: (2017)

Endothelial eNAMPT amplifies pre-clinical acute lung injury: efficacy of an eNAMPT-neutralising monoclonal antibody
por: Quijada, Hector, et al.
Publicado: (2021)

Emerging therapeutic opportunities for integrin inhibitors
por: Slack, R. J., et al.
Publicado: (2021)

Lipogenesis inhibitors: therapeutic opportunities and challenges
por: Batchuluun, Battsetseg, et al.
Publicado: (2022)

The dual face of NAMPT: Intracellular/extracellular protein and diagnostic/therapeutic target in cancer
por: Audrito, Valentina
Publicado: (2020)

From Rate-Limiting Enzyme to Therapeutic Target: The Promise of NAMPT in Neurodegenerative Diseases
por: Zhu, Yumeng, et al.
Publicado: (2022)

A pancreatic ductal adenocarcinoma subpopulation is sensitive to FK866, an inhibitor of NAMPT
por: Barraud, Marine, et al.
Publicado: (2016)

NAMPT Over-Expression Recapitulates the BRAF Inhibitor Resistant Phenotype Plasticity in Melanoma
por: Audrito, Valentina, et al.
Publicado: (2020)

The NAMPT Inhibitor FK866 Increases Metformin Sensitivity in Pancreatic Cancer Cells
por: Parisotto, Maxime, et al.
Publicado: (2022)

The NAMPT Inhibitor FK866 in Combination with Cisplatin Reduces Cholangiocarcinoma Cells Growth
por: Pant, Kishor, et al.
Publicado: (2023)

Liquid Biopsy in Endometrial Cancer: New Opportunities for Personalized Oncology
por: Muinelo-Romay, Laura, et al.
Publicado: (2018)

ATM-Deficient Cancers Provide New Opportunities for Precision Oncology
por: Jette, Nicholas R., et al.
Publicado: (2020)

Expression and Regulation of Nampt in Human Islets
por: Kover, Karen, et al.
Publicado: (2013)

Regulation of Regenerative Periodontal Healing by NAMPT
por: Nokhbehsaim, Marjan, et al.
Publicado: (2013)

Association of Nicotinamide Phosphoribosyltransferase (NAMPT) Gene Polymorphisms and of Serum NAMPT Levels with Dilated Cardiomyopathy in a Chinese Population
por: Dou, Qingyu, et al.
Publicado: (2015)

Endothelial eNAMPT drives EndMT and preclinical PH: rescue by an eNAMPT-neutralizing mAb
por: Ahmed, Mohamed, et al.
Publicado: (2021)

Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators
por: Tang, Siyuan, et al.
Publicado: (2023)

Challenges and Opportunities in Dose Finding in Oncology and Immuno‐oncology
por: Ji, Yan, et al.
Publicado: (2018)

Deubiquitinating Enzymes Related to Autophagy: New Therapeutic Opportunities?
por: Jacomin, Anne-Claire, et al.
Publicado: (2018)

Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology
por: van der Kleij, Maud B. A., et al.
Publicado: (2023)

Iminosugar-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Potential Anti-Pancreatic Cancer Agents
por: Conforti, Irene, et al.
Publicado: (2023)

Protective effects of NAMPT or MAPK inhibitors and NaR on Wallerian degeneration of mammalian axons
por: Alexandris, Athanasios S., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_afk6ebjq4ibbinphce9tf4fbma