Reassessing the role of NAD as a prosurvival factor

The mechanisms regulating the choice of cell demise remain largely unknown. NAD(+), a key metabolite with well-known roles in cell metabolism, has been shown to counteract apoptosis while promoting necroptosis, a form of proinflammatory cell death. This observation identifies NAD(+) availability as...

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Detalles Bibliográficos
Autores principales: Preyat, Nicolas, Leo, Oberdan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845243/
https://www.ncbi.nlm.nih.gov/pubmed/27308572
http://dx.doi.org/10.1080/23723556.2015.1062591
Descripción
Sumario:The mechanisms regulating the choice of cell demise remain largely unknown. NAD(+), a key metabolite with well-known roles in cell metabolism, has been shown to counteract apoptosis while promoting necroptosis, a form of proinflammatory cell death. This observation identifies NAD(+) availability as an important parameter with contrasting roles in the regulation of distinct regulated cell death programs.

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