Reassessing the role of NAD as a prosurvival factor

The mechanisms regulating the choice of cell demise remain largely unknown. NAD(+), a key metabolite with well-known roles in cell metabolism, has been shown to counteract apoptosis while promoting necroptosis, a form of proinflammatory cell death. This observation identifies NAD(+) availability as...

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Detalles Bibliográficos
Autores principales: Preyat, Nicolas, Leo, Oberdan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845243/
https://www.ncbi.nlm.nih.gov/pubmed/27308572
http://dx.doi.org/10.1080/23723556.2015.1062591
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author Preyat, Nicolas
Leo, Oberdan
author_facet Preyat, Nicolas
Leo, Oberdan
author_sort Preyat, Nicolas
collection PubMed
description The mechanisms regulating the choice of cell demise remain largely unknown. NAD(+), a key metabolite with well-known roles in cell metabolism, has been shown to counteract apoptosis while promoting necroptosis, a form of proinflammatory cell death. This observation identifies NAD(+) availability as an important parameter with contrasting roles in the regulation of distinct regulated cell death programs.
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spelling pubmed-48452432016-07-06 Reassessing the role of NAD as a prosurvival factor Preyat, Nicolas Leo, Oberdan Mol Cell Oncol Commentary The mechanisms regulating the choice of cell demise remain largely unknown. NAD(+), a key metabolite with well-known roles in cell metabolism, has been shown to counteract apoptosis while promoting necroptosis, a form of proinflammatory cell death. This observation identifies NAD(+) availability as an important parameter with contrasting roles in the regulation of distinct regulated cell death programs. Taylor & Francis 2015-07-06 /pmc/articles/PMC4845243/ /pubmed/27308572 http://dx.doi.org/10.1080/23723556.2015.1062591 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Commentary
Preyat, Nicolas
Leo, Oberdan
Reassessing the role of NAD as a prosurvival factor
title Reassessing the role of NAD as a prosurvival factor
title_full Reassessing the role of NAD as a prosurvival factor
title_fullStr Reassessing the role of NAD as a prosurvival factor
title_full_unstemmed Reassessing the role of NAD as a prosurvival factor
title_short Reassessing the role of NAD as a prosurvival factor
title_sort reassessing the role of nad as a prosurvival factor
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845243/
https://www.ncbi.nlm.nih.gov/pubmed/27308572
http://dx.doi.org/10.1080/23723556.2015.1062591
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