Chloroquine anticancer activity is mediated by autophagy-independent effects on the tumor vasculature

Chloroquine is used clinically as an autophagy blocker to potentiate anticancer treatments. However, whether chloroquine acts solely through autophagy-dependent and cancer cell autonomous mechanisms has remained elusive. In a recent study we found that chloroquine reduced intratumoral hypoxia and me...

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Detalles Bibliográficos
Autores principales: Maes, Hannelore, Kuchnio, Anna, Carmeliet, Peter, Agostinis, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's Views - Commissioned
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845249/
https://www.ncbi.nlm.nih.gov/pubmed/27308577
http://dx.doi.org/10.4161/23723548.2014.970097
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author Maes, Hannelore
Kuchnio, Anna
Carmeliet, Peter
Agostinis, Patrizia
author_facet Maes, Hannelore
Kuchnio, Anna
Carmeliet, Peter
Agostinis, Patrizia
author_sort Maes, Hannelore
collection PubMed
description Chloroquine is used clinically as an autophagy blocker to potentiate anticancer treatments. However, whether chloroquine acts solely through autophagy-dependent and cancer cell autonomous mechanisms has remained elusive. In a recent study we found that chloroquine reduced intratumoral hypoxia and metastasis, while improving chemotherapy response, largely through an autophagy-independent, NOTCH1-reliant mechanism of tumor vessel normalization.
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spelling pubmed-48452492016-12-09 Chloroquine anticancer activity is mediated by autophagy-independent effects on the tumor vasculature Maes, Hannelore Kuchnio, Anna Carmeliet, Peter Agostinis, Patrizia Mol Cell Oncol Author's Views - Commissioned Chloroquine is used clinically as an autophagy blocker to potentiate anticancer treatments. However, whether chloroquine acts solely through autophagy-dependent and cancer cell autonomous mechanisms has remained elusive. In a recent study we found that chloroquine reduced intratumoral hypoxia and metastasis, while improving chemotherapy response, largely through an autophagy-independent, NOTCH1-reliant mechanism of tumor vessel normalization. Taylor & Francis 2015-12-09 /pmc/articles/PMC4845249/ /pubmed/27308577 http://dx.doi.org/10.4161/23723548.2014.970097 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's Views - Commissioned
Maes, Hannelore
Kuchnio, Anna
Carmeliet, Peter
Agostinis, Patrizia
Chloroquine anticancer activity is mediated by autophagy-independent effects on the tumor vasculature
title Chloroquine anticancer activity is mediated by autophagy-independent effects on the tumor vasculature
title_full Chloroquine anticancer activity is mediated by autophagy-independent effects on the tumor vasculature
title_fullStr Chloroquine anticancer activity is mediated by autophagy-independent effects on the tumor vasculature
title_full_unstemmed Chloroquine anticancer activity is mediated by autophagy-independent effects on the tumor vasculature
title_short Chloroquine anticancer activity is mediated by autophagy-independent effects on the tumor vasculature
title_sort chloroquine anticancer activity is mediated by autophagy-independent effects on the tumor vasculature
topic Author's Views - Commissioned
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845249/
https://www.ncbi.nlm.nih.gov/pubmed/27308577
http://dx.doi.org/10.4161/23723548.2014.970097
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AT carmelietpeter chloroquineanticanceractivityismediatedbyautophagyindependenteffectsonthetumorvasculature
AT agostinispatrizia chloroquineanticanceractivityismediatedbyautophagyindependenteffectsonthetumorvasculature

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