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Defining rules of CD8(+) T cell expansion against pre-erythrocytic Plasmodium antigens in sporozoite-immunized mice

BACKGROUND: Whole Plasmodium sporozoites serve as both experimental tools and potentially as deployable vaccines in the fight against malaria infection. Live sporozoites infect hepatocytes and induce a diverse repertoire of CD8(+) T cell responses, some of which are capable of killing Plasmodium-inf...

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Detalles Bibliográficos
Autores principales: Billman, Zachary P., Kas, Arnold, Stone, Brad C., Murphy, Sean C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845300/
https://www.ncbi.nlm.nih.gov/pubmed/27113469
http://dx.doi.org/10.1186/s12936-016-1295-5