Combined EGFR- and notch inhibition display additive inhibitory effect on glioblastoma cell viability and glioblastoma-induced endothelial cell sprouting in vitro

BACKGROUND: For Glioblastoma (GBM) patients, a number of anti-neoplastic strategies using specifically targeting drugs have been tested; however, the effects on survival have been limited. One explanation could be treatment resistance due to redundant signaling pathways, which substantiates the need...

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Detalles Bibliográficos
Autores principales: Staberg, Mikkel, Michaelsen, Signe Regner, Olsen, Louise Stobbe, Nedergaard, Mette Kjølhede, Villingshøj, Mette, Stockhausen, Marie-Thérése, Hamerlik, Petra, Poulsen, Hans Skovgaard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845362/
https://www.ncbi.nlm.nih.gov/pubmed/27118928
http://dx.doi.org/10.1186/s12935-016-0309-2

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