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Predicting, preventing, and identifying delirium after cardiac surgery
Delirium after cardiac surgery is a major problem. The exact mechanisms behind delirium are not understood. Potential pathways of delirium include neurotransmitter interference, global cognitive disorder, and neuroinflammation. Several predisposing and precipitating risk factors have been identified...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845390/ https://www.ncbi.nlm.nih.gov/pubmed/27119013 http://dx.doi.org/10.1186/s13741-016-0032-5 |
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author | O’Neal, Jason B. Shaw, Andrew D. |
author_facet | O’Neal, Jason B. Shaw, Andrew D. |
author_sort | O’Neal, Jason B. |
collection | PubMed |
description | Delirium after cardiac surgery is a major problem. The exact mechanisms behind delirium are not understood. Potential pathways of delirium include neurotransmitter interference, global cognitive disorder, and neuroinflammation. Several predisposing and precipitating risk factors have been identified for postoperative delirium. The development of delirium following cardiac surgery is associated with worse outcomes in the perioperative period. Multiple interventions are being explored for the prevention and treatment of delirium. Studies investigating the potential roles of biomarkers in delirium as well as pharmacological interventions to reduce the incidence and duration of delirium are necessary to mitigate this negative outcome. |
format | Online Article Text |
id | pubmed-4845390 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-48453902016-04-27 Predicting, preventing, and identifying delirium after cardiac surgery O’Neal, Jason B. Shaw, Andrew D. Perioper Med (Lond) Review Delirium after cardiac surgery is a major problem. The exact mechanisms behind delirium are not understood. Potential pathways of delirium include neurotransmitter interference, global cognitive disorder, and neuroinflammation. Several predisposing and precipitating risk factors have been identified for postoperative delirium. The development of delirium following cardiac surgery is associated with worse outcomes in the perioperative period. Multiple interventions are being explored for the prevention and treatment of delirium. Studies investigating the potential roles of biomarkers in delirium as well as pharmacological interventions to reduce the incidence and duration of delirium are necessary to mitigate this negative outcome. BioMed Central 2016-04-26 /pmc/articles/PMC4845390/ /pubmed/27119013 http://dx.doi.org/10.1186/s13741-016-0032-5 Text en © O’Neal and Shaw. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review O’Neal, Jason B. Shaw, Andrew D. Predicting, preventing, and identifying delirium after cardiac surgery |
title | Predicting, preventing, and identifying delirium after cardiac surgery |
title_full | Predicting, preventing, and identifying delirium after cardiac surgery |
title_fullStr | Predicting, preventing, and identifying delirium after cardiac surgery |
title_full_unstemmed | Predicting, preventing, and identifying delirium after cardiac surgery |
title_short | Predicting, preventing, and identifying delirium after cardiac surgery |
title_sort | predicting, preventing, and identifying delirium after cardiac surgery |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845390/ https://www.ncbi.nlm.nih.gov/pubmed/27119013 http://dx.doi.org/10.1186/s13741-016-0032-5 |
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