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Correlation of Serum Lipoprotein Ratios with Insulin Resistance in Infertile Women with Polycystic Ovarian Syndrome: A Case Control Study
BACKGROUND: Dyslipidemia and insulin resistance (IR), occurring in most infertile women with polycystic ovarian syndrome (PCOS), increase the risk of cardiovascular disease (CVD) and type 2 diabetes. This study aimed to assess the relationships between lipoprotein ratios and IR in PCOS women. MATERI...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royan Institute
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845526/ https://www.ncbi.nlm.nih.gov/pubmed/27123197 |
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author | Ghaffarzad, Aisa Amani, Reza Mehrzad Sadaghiani M.D.3, Mahzad Darabi, Masoud Cheraghian, Bahman |
author_facet | Ghaffarzad, Aisa Amani, Reza Mehrzad Sadaghiani M.D.3, Mahzad Darabi, Masoud Cheraghian, Bahman |
author_sort | Ghaffarzad, Aisa |
collection | PubMed |
description | BACKGROUND: Dyslipidemia and insulin resistance (IR), occurring in most infertile women with polycystic ovarian syndrome (PCOS), increase the risk of cardiovascular disease (CVD) and type 2 diabetes. This study aimed to assess the relationships between lipoprotein ratios and IR in PCOS women. MATERIALS AND METHODS: Thirty six infertile women with PCOS selected based on Androgen Excess Society (AES) criteria and 29 healthy women matched for age were recruited to this case-control study. After physical measurements, fasting serum glucose (Glu), insulin and lipid profile levels [triglycerides (TGs), total cholesterol (TC), low-density lipoproteincholesterol (LDL-C) and high-density lipoprotein-cholesterol (HDL-C)] were measured, while lipoprotein ratios (TC/HDL-C, LDL-C/HDL-C, TG/HDL-C) were calculated. IR was also calculated using homeostasis model assessment (HOMA)-IR. The optimal cutoffs of lipoprotein ratios in relation to HOMA-IR were calculated based on the Receiver Operating Characteristics (ROC) curve analysis using the area under curve (AUC). RESULTS: Waist circumference (WC), insulin levels, HOMA-IR, TG levels, and all lipoprotein ratios were significantly higher, while HDL-C was lower in PCOS group as compared to healthy controls. All lipoprotein ratios, TG levels, and WC are significantly correlated with insulin levels and HOMA-IR. Among lipoprotein ratios, the highest AUC of the ROC belonged to TG/HDL-C ratio with sensitivity of 63.6% and specificity of 84.4% (TG/HDL-C>3.19) as a marker of IR in infertile PCOS women. CONCLUSION: Lipoprotein ratios, particularly TG/HDL-C, are directly correlated with insulin levels and can be used as a marker of IR (HOMA-IR) in infertile PCOS patients. |
format | Online Article Text |
id | pubmed-4845526 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Royan Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-48455262016-04-27 Correlation of Serum Lipoprotein Ratios with Insulin Resistance in Infertile Women with Polycystic Ovarian Syndrome: A Case Control Study Ghaffarzad, Aisa Amani, Reza Mehrzad Sadaghiani M.D.3, Mahzad Darabi, Masoud Cheraghian, Bahman Int J Fertil Steril Original Article BACKGROUND: Dyslipidemia and insulin resistance (IR), occurring in most infertile women with polycystic ovarian syndrome (PCOS), increase the risk of cardiovascular disease (CVD) and type 2 diabetes. This study aimed to assess the relationships between lipoprotein ratios and IR in PCOS women. MATERIALS AND METHODS: Thirty six infertile women with PCOS selected based on Androgen Excess Society (AES) criteria and 29 healthy women matched for age were recruited to this case-control study. After physical measurements, fasting serum glucose (Glu), insulin and lipid profile levels [triglycerides (TGs), total cholesterol (TC), low-density lipoproteincholesterol (LDL-C) and high-density lipoprotein-cholesterol (HDL-C)] were measured, while lipoprotein ratios (TC/HDL-C, LDL-C/HDL-C, TG/HDL-C) were calculated. IR was also calculated using homeostasis model assessment (HOMA)-IR. The optimal cutoffs of lipoprotein ratios in relation to HOMA-IR were calculated based on the Receiver Operating Characteristics (ROC) curve analysis using the area under curve (AUC). RESULTS: Waist circumference (WC), insulin levels, HOMA-IR, TG levels, and all lipoprotein ratios were significantly higher, while HDL-C was lower in PCOS group as compared to healthy controls. All lipoprotein ratios, TG levels, and WC are significantly correlated with insulin levels and HOMA-IR. Among lipoprotein ratios, the highest AUC of the ROC belonged to TG/HDL-C ratio with sensitivity of 63.6% and specificity of 84.4% (TG/HDL-C>3.19) as a marker of IR in infertile PCOS women. CONCLUSION: Lipoprotein ratios, particularly TG/HDL-C, are directly correlated with insulin levels and can be used as a marker of IR (HOMA-IR) in infertile PCOS patients. Royan Institute 2016 2016-04-05 /pmc/articles/PMC4845526/ /pubmed/27123197 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ghaffarzad, Aisa Amani, Reza Mehrzad Sadaghiani M.D.3, Mahzad Darabi, Masoud Cheraghian, Bahman Correlation of Serum Lipoprotein Ratios with Insulin Resistance in Infertile Women with Polycystic Ovarian Syndrome: A Case Control Study |
title | Correlation of Serum Lipoprotein Ratios with Insulin
Resistance in Infertile Women with Polycystic Ovarian
Syndrome: A Case Control Study |
title_full | Correlation of Serum Lipoprotein Ratios with Insulin
Resistance in Infertile Women with Polycystic Ovarian
Syndrome: A Case Control Study |
title_fullStr | Correlation of Serum Lipoprotein Ratios with Insulin
Resistance in Infertile Women with Polycystic Ovarian
Syndrome: A Case Control Study |
title_full_unstemmed | Correlation of Serum Lipoprotein Ratios with Insulin
Resistance in Infertile Women with Polycystic Ovarian
Syndrome: A Case Control Study |
title_short | Correlation of Serum Lipoprotein Ratios with Insulin
Resistance in Infertile Women with Polycystic Ovarian
Syndrome: A Case Control Study |
title_sort | correlation of serum lipoprotein ratios with insulin
resistance in infertile women with polycystic ovarian
syndrome: a case control study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845526/ https://www.ncbi.nlm.nih.gov/pubmed/27123197 |
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