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Aggregated Nanotransfersomal Dry Powder Inhalation of Itraconazole for Pulmonary Drug Delivery

Purpose: Local therapy is a valuable and strategic approach in the treatment of lung associated diseases and dry powder inhalation (DPI) formulations play the key role in this plan. Transfersome has been introduced as a novel biocompatible vesicular system with potential for administration in pulmon...

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Autores principales: Hassanpour Aghdam, Mehdi, Ghanbarzadeh, Saeed, Javadzadeh, Yousef, Hamishehkar, Hamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845537/
https://www.ncbi.nlm.nih.gov/pubmed/27123418
http://dx.doi.org/10.15171/apb.2016.009
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author Hassanpour Aghdam, Mehdi
Ghanbarzadeh, Saeed
Javadzadeh, Yousef
Hamishehkar, Hamed
author_facet Hassanpour Aghdam, Mehdi
Ghanbarzadeh, Saeed
Javadzadeh, Yousef
Hamishehkar, Hamed
author_sort Hassanpour Aghdam, Mehdi
collection PubMed
description Purpose: Local therapy is a valuable and strategic approach in the treatment of lung associated diseases and dry powder inhalation (DPI) formulations play the key role in this plan. Transfersome has been introduced as a novel biocompatible vesicular system with potential for administration in pulmonary drug delivery. The present study was designed to prepare Itraconazole-loaded nanotrantransfersomal DPI formulation. Methods: Itraconazole-loaded nanotransfersomes with three different types of surfactant in varying concentrations were prepared and characterized in the point of particle size distribution and morphology by laser light scattering and scanning electron microscopy (SEM) methods. The optimized transferosomal formulations were co-spray dried with mannitol and the aerosolization efficiency and aerodynamic properties of dry powders were determined by next generation impactor using a validated HPLC technique. Results: The volume mean diameter of optimized nanotransfersomal formulation with lecithin:Span® 60 in the ratio of 90:10 was 171 nm with narrow size distribution pattern which increased up to 518 nm after drug loading. Different types of surfactant did not influence the particle size significantly. SEM images confirmed the formation of aggregated nanoparticles in the suitable range (1-5 µm) for the pulmonary drug delivery. Aerosolization evaluation of co-spray dried formulations with different amounts of mannitol indicated that 2:1 ratio of mannitol:transfersome (w:w) showed the best aerosolization efficiency (fine particle fraction (FPF)=37%). Increasing of mannitol significantly decreased the FPF of the optimized formulations. Conclusion: The results of this study was introduced the potential application of nanotransfersomes in the formulation of DPIs for lung delivery of various drugs.
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spelling pubmed-48455372016-04-27 Aggregated Nanotransfersomal Dry Powder Inhalation of Itraconazole for Pulmonary Drug Delivery Hassanpour Aghdam, Mehdi Ghanbarzadeh, Saeed Javadzadeh, Yousef Hamishehkar, Hamed Adv Pharm Bull Research Article Purpose: Local therapy is a valuable and strategic approach in the treatment of lung associated diseases and dry powder inhalation (DPI) formulations play the key role in this plan. Transfersome has been introduced as a novel biocompatible vesicular system with potential for administration in pulmonary drug delivery. The present study was designed to prepare Itraconazole-loaded nanotrantransfersomal DPI formulation. Methods: Itraconazole-loaded nanotransfersomes with three different types of surfactant in varying concentrations were prepared and characterized in the point of particle size distribution and morphology by laser light scattering and scanning electron microscopy (SEM) methods. The optimized transferosomal formulations were co-spray dried with mannitol and the aerosolization efficiency and aerodynamic properties of dry powders were determined by next generation impactor using a validated HPLC technique. Results: The volume mean diameter of optimized nanotransfersomal formulation with lecithin:Span® 60 in the ratio of 90:10 was 171 nm with narrow size distribution pattern which increased up to 518 nm after drug loading. Different types of surfactant did not influence the particle size significantly. SEM images confirmed the formation of aggregated nanoparticles in the suitable range (1-5 µm) for the pulmonary drug delivery. Aerosolization evaluation of co-spray dried formulations with different amounts of mannitol indicated that 2:1 ratio of mannitol:transfersome (w:w) showed the best aerosolization efficiency (fine particle fraction (FPF)=37%). Increasing of mannitol significantly decreased the FPF of the optimized formulations. Conclusion: The results of this study was introduced the potential application of nanotransfersomes in the formulation of DPIs for lung delivery of various drugs. Tabriz University of Medical Sciences 2016-03 2016-03-17 /pmc/articles/PMC4845537/ /pubmed/27123418 http://dx.doi.org/10.15171/apb.2016.009 Text en ©2016 The Authors. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, as long as the original authors and source are cited. No permission is required from the authors or the publishers.
spellingShingle Research Article
Hassanpour Aghdam, Mehdi
Ghanbarzadeh, Saeed
Javadzadeh, Yousef
Hamishehkar, Hamed
Aggregated Nanotransfersomal Dry Powder Inhalation of Itraconazole for Pulmonary Drug Delivery
title Aggregated Nanotransfersomal Dry Powder Inhalation of Itraconazole for Pulmonary Drug Delivery
title_full Aggregated Nanotransfersomal Dry Powder Inhalation of Itraconazole for Pulmonary Drug Delivery
title_fullStr Aggregated Nanotransfersomal Dry Powder Inhalation of Itraconazole for Pulmonary Drug Delivery
title_full_unstemmed Aggregated Nanotransfersomal Dry Powder Inhalation of Itraconazole for Pulmonary Drug Delivery
title_short Aggregated Nanotransfersomal Dry Powder Inhalation of Itraconazole for Pulmonary Drug Delivery
title_sort aggregated nanotransfersomal dry powder inhalation of itraconazole for pulmonary drug delivery
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845537/
https://www.ncbi.nlm.nih.gov/pubmed/27123418
http://dx.doi.org/10.15171/apb.2016.009
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