Protective Effect of Aortic Stenosis on the Coronary Arteries. Hypothetic Considerations to an Old Enigma

A literature overview of angiographic studies has shown that the prevalence of significant coronary disease in patients with aortic stenosis (AS) varies from 20 to 60%. Early necropsy studies suggested that patients with AS had a lower than expected incidence of coronary artery disease (CAD), origin...

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Autores principales: Evora, Paulo Roberto Barbosa, Arcêncio, Livia, Rodrigues, Alfredo José, Schmidt, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Cardiologia - SBC 2016
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845708/
https://www.ncbi.nlm.nih.gov/pubmed/27142794
http://dx.doi.org/10.5935/abc.20160039
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author Evora, Paulo Roberto Barbosa
Arcêncio, Livia
Rodrigues, Alfredo José
Schmidt, André
author_facet Evora, Paulo Roberto Barbosa
Arcêncio, Livia
Rodrigues, Alfredo José
Schmidt, André
author_sort Evora, Paulo Roberto Barbosa
collection PubMed
description A literature overview of angiographic studies has shown that the prevalence of significant coronary disease in patients with aortic stenosis (AS) varies from 20 to 60%. Early necropsy studies suggested that patients with AS had a lower than expected incidence of coronary artery disease (CAD), originating the concept of a protective effect of AS on the coronary arteries. The myth of AS protection against CAD would be better explained as endothelium-myocardial interaction (crosstalk) protection triggered by left ventricular overload. Therefore, the cGMP/NO pathway induced by the AS overload pressure would explain the low incidence of CAD, which is compatible with the amazing natural long-term evolution of this cardiac valve disease.
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spelling pubmed-48457082016-04-27 Protective Effect of Aortic Stenosis on the Coronary Arteries. Hypothetic Considerations to an Old Enigma Evora, Paulo Roberto Barbosa Arcêncio, Livia Rodrigues, Alfredo José Schmidt, André Arq Bras Cardiol Viewpoint A literature overview of angiographic studies has shown that the prevalence of significant coronary disease in patients with aortic stenosis (AS) varies from 20 to 60%. Early necropsy studies suggested that patients with AS had a lower than expected incidence of coronary artery disease (CAD), originating the concept of a protective effect of AS on the coronary arteries. The myth of AS protection against CAD would be better explained as endothelium-myocardial interaction (crosstalk) protection triggered by left ventricular overload. Therefore, the cGMP/NO pathway induced by the AS overload pressure would explain the low incidence of CAD, which is compatible with the amazing natural long-term evolution of this cardiac valve disease. Sociedade Brasileira de Cardiologia - SBC 2016-04 /pmc/articles/PMC4845708/ /pubmed/27142794 http://dx.doi.org/10.5935/abc.20160039 Text en http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Viewpoint
Evora, Paulo Roberto Barbosa
Arcêncio, Livia
Rodrigues, Alfredo José
Schmidt, André
Protective Effect of Aortic Stenosis on the Coronary Arteries. Hypothetic Considerations to an Old Enigma
title Protective Effect of Aortic Stenosis on the Coronary Arteries. Hypothetic Considerations to an Old Enigma
title_full Protective Effect of Aortic Stenosis on the Coronary Arteries. Hypothetic Considerations to an Old Enigma
title_fullStr Protective Effect of Aortic Stenosis on the Coronary Arteries. Hypothetic Considerations to an Old Enigma
title_full_unstemmed Protective Effect of Aortic Stenosis on the Coronary Arteries. Hypothetic Considerations to an Old Enigma
title_short Protective Effect of Aortic Stenosis on the Coronary Arteries. Hypothetic Considerations to an Old Enigma
title_sort protective effect of aortic stenosis on the coronary arteries. hypothetic considerations to an old enigma
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845708/
https://www.ncbi.nlm.nih.gov/pubmed/27142794
http://dx.doi.org/10.5935/abc.20160039
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