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Prognostic Value of Lymph Node Ratio in Patients Receiving Combined Surgical Resection for Gastric Cancer Liver Metastasis: Results from Two National Centers in China
The purpose of this study was to evaluate the prognostic value of lymph node ratio (LNR) in patients with gastric cancer liver metastasis (GCLM) who received combined surgical resection. A retrospective analysis of 46 patients from two hospitals was conducted. Patients were dichotomized into two gro...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845830/ https://www.ncbi.nlm.nih.gov/pubmed/27100426 http://dx.doi.org/10.1097/MD.0000000000003395 |
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author | Li, Mu-Xing Jin, Zheng-Xiong Zhou, Jian-Guo Ying, Jian-Ming Liang, Zhi-Yong Mao, Xin-Xin Bi, Xin-Yu Zhao, Jian-Jun Li, Zhi-Yu Huang, Zhen Zhang, Ye-Fan Li, Yuan Chen, Xiao Hu, Xu-Hui Hu, Han-Jie Zhao, Dong-Bing Wang, Ying-Yi Cai, Jian-Qiang Zhao, Hong |
author_facet | Li, Mu-Xing Jin, Zheng-Xiong Zhou, Jian-Guo Ying, Jian-Ming Liang, Zhi-Yong Mao, Xin-Xin Bi, Xin-Yu Zhao, Jian-Jun Li, Zhi-Yu Huang, Zhen Zhang, Ye-Fan Li, Yuan Chen, Xiao Hu, Xu-Hui Hu, Han-Jie Zhao, Dong-Bing Wang, Ying-Yi Cai, Jian-Qiang Zhao, Hong |
author_sort | Li, Mu-Xing |
collection | PubMed |
description | The purpose of this study was to evaluate the prognostic value of lymph node ratio (LNR) in patients with gastric cancer liver metastasis (GCLM) who received combined surgical resection. A retrospective analysis of 46 patients from two hospitals was conducted. Patients were dichotomized into two groups (high LNR and low LNR) by the median value of LNR. The overall survival (OS) and recurrence-free survival (RFS) were analyzed by the Kaplan–Meier method with the log-rank test. The Cox proportional hazard model was used to carry out the subsequent multivariate analyses. And the relationship between LNR and clinicopathological characteristics was assessed. The cut-off value defining elevated LNR was 0.347. With a median follow-up of 67.5 months, the median OS and RFS of the patients were 17 and 9.5 months, respectively. Six patients survived for >5 years after surgery. Patients with higher LNR had significantly shorter OS and RFS than those with lower LNR. In the multivariate analyses, higher LNR and multiple liver metastatic tumors were identified as the independent prognostic factors for both OS and RFS. Elevated LNR was significantly associated with advanced pN stage (P <0.001), larger primary tumor size (P = 0.046), the presence of microvascular invasion (P = 0.008), and neoadjuvant chemotherapy (P = 0.004). LNR may be prognostic indicator for patients with GCLM treated by synchronous surgical resection. Patients with lower LNR and single liver metastasis may gain more survival benefits from the surgical resection. Further prospective studies with reasonable study design are warranted. |
format | Online Article Text |
id | pubmed-4845830 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-48458302016-05-16 Prognostic Value of Lymph Node Ratio in Patients Receiving Combined Surgical Resection for Gastric Cancer Liver Metastasis: Results from Two National Centers in China Li, Mu-Xing Jin, Zheng-Xiong Zhou, Jian-Guo Ying, Jian-Ming Liang, Zhi-Yong Mao, Xin-Xin Bi, Xin-Yu Zhao, Jian-Jun Li, Zhi-Yu Huang, Zhen Zhang, Ye-Fan Li, Yuan Chen, Xiao Hu, Xu-Hui Hu, Han-Jie Zhao, Dong-Bing Wang, Ying-Yi Cai, Jian-Qiang Zhao, Hong Medicine (Baltimore) 7100 The purpose of this study was to evaluate the prognostic value of lymph node ratio (LNR) in patients with gastric cancer liver metastasis (GCLM) who received combined surgical resection. A retrospective analysis of 46 patients from two hospitals was conducted. Patients were dichotomized into two groups (high LNR and low LNR) by the median value of LNR. The overall survival (OS) and recurrence-free survival (RFS) were analyzed by the Kaplan–Meier method with the log-rank test. The Cox proportional hazard model was used to carry out the subsequent multivariate analyses. And the relationship between LNR and clinicopathological characteristics was assessed. The cut-off value defining elevated LNR was 0.347. With a median follow-up of 67.5 months, the median OS and RFS of the patients were 17 and 9.5 months, respectively. Six patients survived for >5 years after surgery. Patients with higher LNR had significantly shorter OS and RFS than those with lower LNR. In the multivariate analyses, higher LNR and multiple liver metastatic tumors were identified as the independent prognostic factors for both OS and RFS. Elevated LNR was significantly associated with advanced pN stage (P <0.001), larger primary tumor size (P = 0.046), the presence of microvascular invasion (P = 0.008), and neoadjuvant chemotherapy (P = 0.004). LNR may be prognostic indicator for patients with GCLM treated by synchronous surgical resection. Patients with lower LNR and single liver metastasis may gain more survival benefits from the surgical resection. Further prospective studies with reasonable study design are warranted. Wolters Kluwer Health 2016-04-22 /pmc/articles/PMC4845830/ /pubmed/27100426 http://dx.doi.org/10.1097/MD.0000000000003395 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 7100 Li, Mu-Xing Jin, Zheng-Xiong Zhou, Jian-Guo Ying, Jian-Ming Liang, Zhi-Yong Mao, Xin-Xin Bi, Xin-Yu Zhao, Jian-Jun Li, Zhi-Yu Huang, Zhen Zhang, Ye-Fan Li, Yuan Chen, Xiao Hu, Xu-Hui Hu, Han-Jie Zhao, Dong-Bing Wang, Ying-Yi Cai, Jian-Qiang Zhao, Hong Prognostic Value of Lymph Node Ratio in Patients Receiving Combined Surgical Resection for Gastric Cancer Liver Metastasis: Results from Two National Centers in China |
title | Prognostic Value of Lymph Node Ratio in Patients Receiving Combined Surgical Resection for Gastric Cancer Liver Metastasis: Results from Two National Centers in China |
title_full | Prognostic Value of Lymph Node Ratio in Patients Receiving Combined Surgical Resection for Gastric Cancer Liver Metastasis: Results from Two National Centers in China |
title_fullStr | Prognostic Value of Lymph Node Ratio in Patients Receiving Combined Surgical Resection for Gastric Cancer Liver Metastasis: Results from Two National Centers in China |
title_full_unstemmed | Prognostic Value of Lymph Node Ratio in Patients Receiving Combined Surgical Resection for Gastric Cancer Liver Metastasis: Results from Two National Centers in China |
title_short | Prognostic Value of Lymph Node Ratio in Patients Receiving Combined Surgical Resection for Gastric Cancer Liver Metastasis: Results from Two National Centers in China |
title_sort | prognostic value of lymph node ratio in patients receiving combined surgical resection for gastric cancer liver metastasis: results from two national centers in china |
topic | 7100 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845830/ https://www.ncbi.nlm.nih.gov/pubmed/27100426 http://dx.doi.org/10.1097/MD.0000000000003395 |
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