Quantification of active mitochondrial permeability transition pores using GNX-4975 inhibitor titrations provides insights into molecular identity

Inhibition of the mitochondrial permeability transition pore (MPTP) by the novel inhibitor GNX-4975 was characterized. Titration of MPTP activity in de-energized rat liver mitochondria allowed determination of the number of GNX-4975-binding sites and their dissociation constant (K(i)). Binding sites...

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Detalles Bibliográficos
Autores principales: Richardson, Andrew P., Halestrap, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845862/
https://www.ncbi.nlm.nih.gov/pubmed/26920024
http://dx.doi.org/10.1042/BCJ20160070

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