Generation and characterization of ixekizumab, a humanized monoclonal antibody that neutralizes interleukin-17A

Interleukin (IL)-17A exists as a homodimer (A/A) or as a heterodimer (A/F) with IL-17F. IL-17A is expressed by a subset of T-cells, called Th17 cells, at inflammatory sites. Most cell types can respond to the local production of IL-17A because of the near ubiquitous expression of IL-17A receptors, I...

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Detalles Bibliográficos
Autores principales: Liu, Ling, Lu, Jirong, Allan, Barrett W, Tang, Ying, Tetreault, Jonathan, Chow, Chi-kin, Barmettler, Barbra, Nelson, James, Bina, Holly, Huang, Lihua, Wroblewski, Victor J, Kikly, Kristine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846058/
https://www.ncbi.nlm.nih.gov/pubmed/27143947
http://dx.doi.org/10.2147/JIR.S100940

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