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Glucocorticoids accelerate maturation of the heme pathway in fetal liver through effects on transcription and DNA methylation
Glucocorticoids are widely used in threatened preterm labor to promote maturation in many organ systems in preterm babies and have significant beneficial effects on morbidity and mortality. We performed transcriptional profiling in fetal liver in a rat model of prenatal glucocorticoid exposure and i...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846099/ https://www.ncbi.nlm.nih.gov/pubmed/26889791 http://dx.doi.org/10.1080/15592294.2016.1144006 |
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author | Khulan, Batbayar Liu, Lincoln Rose, Catherine M. Boyle, Ashley K. Manning, Jonathan R. Drake, Amanda J. |
author_facet | Khulan, Batbayar Liu, Lincoln Rose, Catherine M. Boyle, Ashley K. Manning, Jonathan R. Drake, Amanda J. |
author_sort | Khulan, Batbayar |
collection | PubMed |
description | Glucocorticoids are widely used in threatened preterm labor to promote maturation in many organ systems in preterm babies and have significant beneficial effects on morbidity and mortality. We performed transcriptional profiling in fetal liver in a rat model of prenatal glucocorticoid exposure and identified marked gene expression changes in heme biosynthesis, utilization, and degradation pathways in late gestation. These changes in gene expression associated with alterations in DNA methylation and with a reduction in hepatic heme concentration. There were no persistent differences in gene expression, DNA methylation, or heme concentrations at 4 weeks of age, suggesting that these are transient effects. Our findings are consistent with glucocorticoid-induced accelerated maturation of the haematopoietic system and support the hypothesis that glucocorticoids can drive changes in gene expression in association with alterations in DNA methylation. |
format | Online Article Text |
id | pubmed-4846099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-48460992016-05-09 Glucocorticoids accelerate maturation of the heme pathway in fetal liver through effects on transcription and DNA methylation Khulan, Batbayar Liu, Lincoln Rose, Catherine M. Boyle, Ashley K. Manning, Jonathan R. Drake, Amanda J. Epigenetics Brief Report Glucocorticoids are widely used in threatened preterm labor to promote maturation in many organ systems in preterm babies and have significant beneficial effects on morbidity and mortality. We performed transcriptional profiling in fetal liver in a rat model of prenatal glucocorticoid exposure and identified marked gene expression changes in heme biosynthesis, utilization, and degradation pathways in late gestation. These changes in gene expression associated with alterations in DNA methylation and with a reduction in hepatic heme concentration. There were no persistent differences in gene expression, DNA methylation, or heme concentrations at 4 weeks of age, suggesting that these are transient effects. Our findings are consistent with glucocorticoid-induced accelerated maturation of the haematopoietic system and support the hypothesis that glucocorticoids can drive changes in gene expression in association with alterations in DNA methylation. Taylor & Francis 2016-02-18 /pmc/articles/PMC4846099/ /pubmed/26889791 http://dx.doi.org/10.1080/15592294.2016.1144006 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
spellingShingle | Brief Report Khulan, Batbayar Liu, Lincoln Rose, Catherine M. Boyle, Ashley K. Manning, Jonathan R. Drake, Amanda J. Glucocorticoids accelerate maturation of the heme pathway in fetal liver through effects on transcription and DNA methylation |
title | Glucocorticoids accelerate maturation of the heme pathway in fetal liver through effects on transcription and DNA methylation |
title_full | Glucocorticoids accelerate maturation of the heme pathway in fetal liver through effects on transcription and DNA methylation |
title_fullStr | Glucocorticoids accelerate maturation of the heme pathway in fetal liver through effects on transcription and DNA methylation |
title_full_unstemmed | Glucocorticoids accelerate maturation of the heme pathway in fetal liver through effects on transcription and DNA methylation |
title_short | Glucocorticoids accelerate maturation of the heme pathway in fetal liver through effects on transcription and DNA methylation |
title_sort | glucocorticoids accelerate maturation of the heme pathway in fetal liver through effects on transcription and dna methylation |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846099/ https://www.ncbi.nlm.nih.gov/pubmed/26889791 http://dx.doi.org/10.1080/15592294.2016.1144006 |
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