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The global antigenic diversity of swine influenza A viruses
Swine influenza presents a substantial disease burden for pig populations worldwide and poses a potential pandemic threat to humans. There is considerable diversity in both H1 and H3 influenza viruses circulating in swine due to the frequent introductions of viruses from humans and birds coupled wit...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846380/ https://www.ncbi.nlm.nih.gov/pubmed/27113719 http://dx.doi.org/10.7554/eLife.12217 |
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| author | Lewis, Nicola S Russell, Colin A Langat, Pinky Anderson, Tavis K Berger, Kathryn Bielejec, Filip Burke, David F Dudas, Gytis Fonville, Judith M Fouchier, Ron AM Kellam, Paul Koel, Bjorn F Lemey, Philippe Nguyen, Tung Nuansrichy, Bundit Peiris, JS Malik Saito, Takehiko Simon, Gaelle Skepner, Eugene Takemae, Nobuhiro Webby, Richard J Van Reeth, Kristien Brookes, Sharon M Larsen, Lars Watson, Simon J Brown, Ian H Vincent, Amy L |
| author_facet | Lewis, Nicola S Russell, Colin A Langat, Pinky Anderson, Tavis K Berger, Kathryn Bielejec, Filip Burke, David F Dudas, Gytis Fonville, Judith M Fouchier, Ron AM Kellam, Paul Koel, Bjorn F Lemey, Philippe Nguyen, Tung Nuansrichy, Bundit Peiris, JS Malik Saito, Takehiko Simon, Gaelle Skepner, Eugene Takemae, Nobuhiro Webby, Richard J Van Reeth, Kristien Brookes, Sharon M Larsen, Lars Watson, Simon J Brown, Ian H Vincent, Amy L |
| author_sort | Lewis, Nicola S |
| collection | PubMed |
| description | Swine influenza presents a substantial disease burden for pig populations worldwide and poses a potential pandemic threat to humans. There is considerable diversity in both H1 and H3 influenza viruses circulating in swine due to the frequent introductions of viruses from humans and birds coupled with geographic segregation of global swine populations. Much of this diversity is characterized genetically but the antigenic diversity of these viruses is poorly understood. Critically, the antigenic diversity shapes the risk profile of swine influenza viruses in terms of their epizootic and pandemic potential. Here, using the most comprehensive set of swine influenza virus antigenic data compiled to date, we quantify the antigenic diversity of swine influenza viruses on a multi-continental scale. The substantial antigenic diversity of recently circulating viruses in different parts of the world adds complexity to the risk profiles for the movement of swine and the potential for swine-derived infections in humans. DOI: http://dx.doi.org/10.7554/eLife.12217.001 |
| format | Online Article Text |
| id | pubmed-4846380 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | eLife Sciences Publications, Ltd |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-48463802016-04-28 The global antigenic diversity of swine influenza A viruses Lewis, Nicola S Russell, Colin A Langat, Pinky Anderson, Tavis K Berger, Kathryn Bielejec, Filip Burke, David F Dudas, Gytis Fonville, Judith M Fouchier, Ron AM Kellam, Paul Koel, Bjorn F Lemey, Philippe Nguyen, Tung Nuansrichy, Bundit Peiris, JS Malik Saito, Takehiko Simon, Gaelle Skepner, Eugene Takemae, Nobuhiro Webby, Richard J Van Reeth, Kristien Brookes, Sharon M Larsen, Lars Watson, Simon J Brown, Ian H Vincent, Amy L eLife Epidemiology and Global Health Swine influenza presents a substantial disease burden for pig populations worldwide and poses a potential pandemic threat to humans. There is considerable diversity in both H1 and H3 influenza viruses circulating in swine due to the frequent introductions of viruses from humans and birds coupled with geographic segregation of global swine populations. Much of this diversity is characterized genetically but the antigenic diversity of these viruses is poorly understood. Critically, the antigenic diversity shapes the risk profile of swine influenza viruses in terms of their epizootic and pandemic potential. Here, using the most comprehensive set of swine influenza virus antigenic data compiled to date, we quantify the antigenic diversity of swine influenza viruses on a multi-continental scale. The substantial antigenic diversity of recently circulating viruses in different parts of the world adds complexity to the risk profiles for the movement of swine and the potential for swine-derived infections in humans. DOI: http://dx.doi.org/10.7554/eLife.12217.001 eLife Sciences Publications, Ltd 2016-04-22 /pmc/articles/PMC4846380/ /pubmed/27113719 http://dx.doi.org/10.7554/eLife.12217 Text en © 2016, Lewis et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
| spellingShingle | Epidemiology and Global Health Lewis, Nicola S Russell, Colin A Langat, Pinky Anderson, Tavis K Berger, Kathryn Bielejec, Filip Burke, David F Dudas, Gytis Fonville, Judith M Fouchier, Ron AM Kellam, Paul Koel, Bjorn F Lemey, Philippe Nguyen, Tung Nuansrichy, Bundit Peiris, JS Malik Saito, Takehiko Simon, Gaelle Skepner, Eugene Takemae, Nobuhiro Webby, Richard J Van Reeth, Kristien Brookes, Sharon M Larsen, Lars Watson, Simon J Brown, Ian H Vincent, Amy L The global antigenic diversity of swine influenza A viruses |
| title | The global antigenic diversity of swine influenza A viruses |
| title_full | The global antigenic diversity of swine influenza A viruses |
| title_fullStr | The global antigenic diversity of swine influenza A viruses |
| title_full_unstemmed | The global antigenic diversity of swine influenza A viruses |
| title_short | The global antigenic diversity of swine influenza A viruses |
| title_sort | global antigenic diversity of swine influenza a viruses |
| topic | Epidemiology and Global Health |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846380/ https://www.ncbi.nlm.nih.gov/pubmed/27113719 http://dx.doi.org/10.7554/eLife.12217 |
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