Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration

mTOR inhibition is beneficial in neurodegenerative disease models and its effects are often attributable to the modulation of autophagy and anti-apoptosis. Here, we report a neglected but important bioenergetic effect of mTOR inhibition in neurons. mTOR inhibition by rapamycin significantly preserve...

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Detalles Bibliográficos
Autores principales: Zheng, Xinde, Boyer, Leah, Jin, Mingji, Kim, Yongsung, Fan, Weiwei, Bardy, Cedric, Berggren, Travis, Evans, Ronald M, Gage, Fred H, Hunter, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846388/
https://www.ncbi.nlm.nih.gov/pubmed/27008180
http://dx.doi.org/10.7554/eLife.13378

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