Huntingtin’s spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function

The polyglutamine expansion in huntingtin protein causes Huntington’s disease. Here, we investigated structural and biochemical properties of huntingtin and the effect of the polyglutamine expansion using various biophysical experiments including circular dichroism, single-particle electron microsco...

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Detalles Bibliográficos
Autores principales: Vijayvargia, Ravi, Epand, Raquel, Leitner, Alexander, Jung, Tae-Yang, Shin, Baehyun, Jung, Roy, Lloret, Alejandro, Singh Atwal, Randy, Lee, Hyeongseok, Lee, Jong-Min, Aebersold, Ruedi, Hebert, Hans, Song, Ji-Joon, Seong, Ihn Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846397/
https://www.ncbi.nlm.nih.gov/pubmed/27003594
http://dx.doi.org/10.7554/eLife.11184

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