Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B cell acute lymphoblastic leukemia

STAT5 activation occurs frequently in human progenitor B cell acute lymphoblastic leukemia (B-ALL). To identify gene alterations that cooperate with STAT5 activation to initiate leukemia we crossed mice expressing a constitutively active form of STAT5 (Stat5b-CA) to mice in which a mutagenic Sleepin...

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Detalles Bibliográficos
Autores principales: Heltemes-Harris, Lynn M., Larson, Jon D., Starr, Timothy K., Hubbard, Gregory K., Sarver, Aaron L., Largaespada, David A., Farrar, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846597/
https://www.ncbi.nlm.nih.gov/pubmed/26500062
http://dx.doi.org/10.1038/onc.2015.405

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