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MEK inhibitor can reverse the resistance to bevacizumab in A549 cells harboring Kirsten rat sarcoma oncogene homolog mutation

BACKGROUND: Bevacizumab (BV) is broadly used to treat a number of cancers; however, BV resistance mechanisms and strategies to overcome this resistance are yet to be determined. METHODS: We established xenograft mice models harboring Kirsten rat sarcoma oncogene homolog (KRAS) mutations based on the...

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Detalles Bibliográficos
Autores principales:	Wang, Yuan, Yan, Ping, Liu, Zhentao, Yang, Xiaodan, Wang, Yaping, Shen, Zhirong, Bai, Hua, Wang, Jie, Wang, Zhijie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846615/ https://www.ncbi.nlm.nih.gov/pubmed/27148412 http://dx.doi.org/10.1111/1759-7714.12325

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