Response to crizotinib in a squamous cell lung carcinoma patient harbouring echinoderm microtubule‐associated protein‐like 4‐anaplastic lymphoma translocation: A case report

Squamous cell lung cancer (SCC) presenting with anaplastic lymphoma kinase (ALK) translocation is rare. We present a case of ALK gene translocation‐SCC in which a remarkable tumor response to crizotinib was achieved after the failure of prior chemoradiotherapy. Considering this remarkable response,...

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Detalles Bibliográficos
Autores principales: Wang, Wenxian, Song, Zhengbo, Zhang, Yiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846625/
https://www.ncbi.nlm.nih.gov/pubmed/27148422
http://dx.doi.org/10.1111/1759-7714.12298
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author Wang, Wenxian
Song, Zhengbo
Zhang, Yiping
author_facet Wang, Wenxian
Song, Zhengbo
Zhang, Yiping
author_sort Wang, Wenxian
collection PubMed
description Squamous cell lung cancer (SCC) presenting with anaplastic lymphoma kinase (ALK) translocation is rare. We present a case of ALK gene translocation‐SCC in which a remarkable tumor response to crizotinib was achieved after the failure of prior chemoradiotherapy. Considering this remarkable response, we conclude that ALK testing in female non‐smokers or in any patient unresponsive to the initial regimen of chemotherapy, is recommended for SCC patients.
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spelling pubmed-48466252016-05-04 Response to crizotinib in a squamous cell lung carcinoma patient harbouring echinoderm microtubule‐associated protein‐like 4‐anaplastic lymphoma translocation: A case report Wang, Wenxian Song, Zhengbo Zhang, Yiping Thorac Cancer Case Reports Squamous cell lung cancer (SCC) presenting with anaplastic lymphoma kinase (ALK) translocation is rare. We present a case of ALK gene translocation‐SCC in which a remarkable tumor response to crizotinib was achieved after the failure of prior chemoradiotherapy. Considering this remarkable response, we conclude that ALK testing in female non‐smokers or in any patient unresponsive to the initial regimen of chemotherapy, is recommended for SCC patients. John Wiley and Sons Inc. 2015-07-29 2016-04-26 /pmc/articles/PMC4846625/ /pubmed/27148422 http://dx.doi.org/10.1111/1759-7714.12298 Text en © 2015 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Wang, Wenxian
Song, Zhengbo
Zhang, Yiping
Response to crizotinib in a squamous cell lung carcinoma patient harbouring echinoderm microtubule‐associated protein‐like 4‐anaplastic lymphoma translocation: A case report
title Response to crizotinib in a squamous cell lung carcinoma patient harbouring echinoderm microtubule‐associated protein‐like 4‐anaplastic lymphoma translocation: A case report
title_full Response to crizotinib in a squamous cell lung carcinoma patient harbouring echinoderm microtubule‐associated protein‐like 4‐anaplastic lymphoma translocation: A case report
title_fullStr Response to crizotinib in a squamous cell lung carcinoma patient harbouring echinoderm microtubule‐associated protein‐like 4‐anaplastic lymphoma translocation: A case report
title_full_unstemmed Response to crizotinib in a squamous cell lung carcinoma patient harbouring echinoderm microtubule‐associated protein‐like 4‐anaplastic lymphoma translocation: A case report
title_short Response to crizotinib in a squamous cell lung carcinoma patient harbouring echinoderm microtubule‐associated protein‐like 4‐anaplastic lymphoma translocation: A case report
title_sort response to crizotinib in a squamous cell lung carcinoma patient harbouring echinoderm microtubule‐associated protein‐like 4‐anaplastic lymphoma translocation: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846625/
https://www.ncbi.nlm.nih.gov/pubmed/27148422
http://dx.doi.org/10.1111/1759-7714.12298
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AT songzhengbo responsetocrizotinibinasquamouscelllungcarcinomapatientharbouringechinodermmicrotubuleassociatedproteinlike4anaplasticlymphomatranslocationacasereport
AT zhangyiping responsetocrizotinibinasquamouscelllungcarcinomapatientharbouringechinodermmicrotubuleassociatedproteinlike4anaplasticlymphomatranslocationacasereport

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