A hybrid system with highly enhanced graphene SERS for rapid and tag-free tumor cells detection

By dint of unique physical/chemical properties and bio-compatibility, graphene can work as a building block for a SERS substrate and open up a unique platform for tumor cells detection with high sensitivity. Herein we demonstrate a facile system with highly enhanced surface enhanced Raman spectrosco...

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Detalles Bibliográficos
Autores principales: Yi, Ningbo, Zhang, Chen, Song, Qinghai, Xiao, Shumin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846833/
https://www.ncbi.nlm.nih.gov/pubmed/27118247
http://dx.doi.org/10.1038/srep25134
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author Yi, Ningbo
Zhang, Chen
Song, Qinghai
Xiao, Shumin
author_facet Yi, Ningbo
Zhang, Chen
Song, Qinghai
Xiao, Shumin
author_sort Yi, Ningbo
collection PubMed
description By dint of unique physical/chemical properties and bio-compatibility, graphene can work as a building block for a SERS substrate and open up a unique platform for tumor cells detection with high sensitivity. Herein we demonstrate a facile system with highly enhanced surface enhanced Raman spectroscopy of graphene (G-SERS). The system consists of a reduced graphene oxide (rGO) sandwiched by silver and gold nanostructures. Due to the ultrasmall thickness of rGO, the inter-coupling between Ag and Au nanoparticles is precisely controlled and the local field enhancement has been improved to more than 70 times. Associated with the unique chemical mechanism of rGO, the hybrid system has been utilized to identify tumor cells without using any biomarkers. We believe this research will be important for the applications of rGO in cancer screening.
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spelling pubmed-48468332016-05-04 A hybrid system with highly enhanced graphene SERS for rapid and tag-free tumor cells detection Yi, Ningbo Zhang, Chen Song, Qinghai Xiao, Shumin Sci Rep Article By dint of unique physical/chemical properties and bio-compatibility, graphene can work as a building block for a SERS substrate and open up a unique platform for tumor cells detection with high sensitivity. Herein we demonstrate a facile system with highly enhanced surface enhanced Raman spectroscopy of graphene (G-SERS). The system consists of a reduced graphene oxide (rGO) sandwiched by silver and gold nanostructures. Due to the ultrasmall thickness of rGO, the inter-coupling between Ag and Au nanoparticles is precisely controlled and the local field enhancement has been improved to more than 70 times. Associated with the unique chemical mechanism of rGO, the hybrid system has been utilized to identify tumor cells without using any biomarkers. We believe this research will be important for the applications of rGO in cancer screening. Nature Publishing Group 2016-04-27 /pmc/articles/PMC4846833/ /pubmed/27118247 http://dx.doi.org/10.1038/srep25134 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Yi, Ningbo
Zhang, Chen
Song, Qinghai
Xiao, Shumin
A hybrid system with highly enhanced graphene SERS for rapid and tag-free tumor cells detection
title A hybrid system with highly enhanced graphene SERS for rapid and tag-free tumor cells detection
title_full A hybrid system with highly enhanced graphene SERS for rapid and tag-free tumor cells detection
title_fullStr A hybrid system with highly enhanced graphene SERS for rapid and tag-free tumor cells detection
title_full_unstemmed A hybrid system with highly enhanced graphene SERS for rapid and tag-free tumor cells detection
title_short A hybrid system with highly enhanced graphene SERS for rapid and tag-free tumor cells detection
title_sort hybrid system with highly enhanced graphene sers for rapid and tag-free tumor cells detection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846833/
https://www.ncbi.nlm.nih.gov/pubmed/27118247
http://dx.doi.org/10.1038/srep25134
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