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A ‘complex’ of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients

Despite the prevalence of migraine, the pathophysiology of the disease remains unclear. Current understanding of migraine has alluded to the possibility of a hyperexcitable brain. The aim of the current study is to investigate human brain metabolite differences in the anterior cingulate cortex (ACC)...

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Autores principales: Becerra, L., Veggeberg, R., Prescot, A., Jensen, J.E., Renshaw, P., Scrivani, S., Spierings, E.L.H., Burstein, R., Borsook, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846856/
https://www.ncbi.nlm.nih.gov/pubmed/27158591
http://dx.doi.org/10.1016/j.nicl.2016.03.020
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author Becerra, L.
Veggeberg, R.
Prescot, A.
Jensen, J.E.
Renshaw, P.
Scrivani, S.
Spierings, E.L.H.
Burstein, R.
Borsook, D.
author_facet Becerra, L.
Veggeberg, R.
Prescot, A.
Jensen, J.E.
Renshaw, P.
Scrivani, S.
Spierings, E.L.H.
Burstein, R.
Borsook, D.
author_sort Becerra, L.
collection PubMed
description Despite the prevalence of migraine, the pathophysiology of the disease remains unclear. Current understanding of migraine has alluded to the possibility of a hyperexcitable brain. The aim of the current study is to investigate human brain metabolite differences in the anterior cingulate cortex (ACC) during the interictal phase in migraine patients. We hypothesized that there may be differences in levels of excitatory neurotransmitters and/or their derivatives in the migraine cohort in support of the theory of hyperexcitability in migraine. 2D J-resolved proton magnetic resonance spectroscopy ((1)H-MRS) data were acquired on a 3 Tesla (3 T) MRI from a voxel placed over the ACC of 32 migraine patients (MP; 23 females, 9 males, age 33 ± 9.6 years) and 33 healthy controls (HC; 25 females, 8 males, age 32 ± 9.6 years). Amplitude correlation matrices were constructed for each subject to evaluate metabolite discriminability. ProFit-estimated metabolite peak areas were normalized to a water reference signal to assess subject differences. The initial analysis of variance (ANOVA) was performed to test for group differences for all metabolites/creatine (Cre) ratios between healthy controls and migraineurs but showed no statistically significant differences. In addition, we used a multivariate approach to distinguish migraineurs from healthy subjects based on the metabolite/Cre ratio. A quadratic discriminant analysis (QDA) model was used to identify 3 metabolite ratios sufficient to minimize minimum classification error (MCE). The 3 selected metabolite ratios were aspartate (Asp)/Cre, N-acetyl aspartate (NAA)/Cre, and glutamine (Gln)/Cre. These findings are in support of a ‘complex’ of metabolite alterations, which may underlie changes in neuronal chemistry in the migraine brain. Furthermore, the parallel changes in the three-metabolite ‘complex’ may confer more subtle but biological processes that are ongoing. The data also support the current theory that the migraine brain is hyperexcitable even in the interictal state.
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spelling pubmed-48468562016-05-06 A ‘complex’ of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients Becerra, L. Veggeberg, R. Prescot, A. Jensen, J.E. Renshaw, P. Scrivani, S. Spierings, E.L.H. Burstein, R. Borsook, D. Neuroimage Clin Regular Article Despite the prevalence of migraine, the pathophysiology of the disease remains unclear. Current understanding of migraine has alluded to the possibility of a hyperexcitable brain. The aim of the current study is to investigate human brain metabolite differences in the anterior cingulate cortex (ACC) during the interictal phase in migraine patients. We hypothesized that there may be differences in levels of excitatory neurotransmitters and/or their derivatives in the migraine cohort in support of the theory of hyperexcitability in migraine. 2D J-resolved proton magnetic resonance spectroscopy ((1)H-MRS) data were acquired on a 3 Tesla (3 T) MRI from a voxel placed over the ACC of 32 migraine patients (MP; 23 females, 9 males, age 33 ± 9.6 years) and 33 healthy controls (HC; 25 females, 8 males, age 32 ± 9.6 years). Amplitude correlation matrices were constructed for each subject to evaluate metabolite discriminability. ProFit-estimated metabolite peak areas were normalized to a water reference signal to assess subject differences. The initial analysis of variance (ANOVA) was performed to test for group differences for all metabolites/creatine (Cre) ratios between healthy controls and migraineurs but showed no statistically significant differences. In addition, we used a multivariate approach to distinguish migraineurs from healthy subjects based on the metabolite/Cre ratio. A quadratic discriminant analysis (QDA) model was used to identify 3 metabolite ratios sufficient to minimize minimum classification error (MCE). The 3 selected metabolite ratios were aspartate (Asp)/Cre, N-acetyl aspartate (NAA)/Cre, and glutamine (Gln)/Cre. These findings are in support of a ‘complex’ of metabolite alterations, which may underlie changes in neuronal chemistry in the migraine brain. Furthermore, the parallel changes in the three-metabolite ‘complex’ may confer more subtle but biological processes that are ongoing. The data also support the current theory that the migraine brain is hyperexcitable even in the interictal state. Elsevier 2016-03-31 /pmc/articles/PMC4846856/ /pubmed/27158591 http://dx.doi.org/10.1016/j.nicl.2016.03.020 Text en © 2016 The Authors. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Becerra, L.
Veggeberg, R.
Prescot, A.
Jensen, J.E.
Renshaw, P.
Scrivani, S.
Spierings, E.L.H.
Burstein, R.
Borsook, D.
A ‘complex’ of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients
title A ‘complex’ of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients
title_full A ‘complex’ of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients
title_fullStr A ‘complex’ of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients
title_full_unstemmed A ‘complex’ of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients
title_short A ‘complex’ of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients
title_sort ‘complex’ of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846856/
https://www.ncbi.nlm.nih.gov/pubmed/27158591
http://dx.doi.org/10.1016/j.nicl.2016.03.020
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