In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity

According to in vitro assays, T cells are thought to kill rapidly and efficiently, but the efficacy and dynamics of cytotoxic T lymphocyte (CTL)-mediated killing of virus-infected cells in vivo remains elusive. We used two-photon microscopy to quantify CTL-mediated killing in mice infected with herp...

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Detalles Bibliográficos
Autores principales: Halle, Stephan, Keyser, Kirsten Anja, Stahl, Felix Rolf, Busche, Andreas, Marquardt, Anja, Zheng, Xiang, Galla, Melanie, Heissmeyer, Vigo, Heller, Katrin, Boelter, Jasmin, Wagner, Karen, Bischoff, Yvonne, Martens, Rieke, Braun, Asolina, Werth, Kathrin, Uvarovskii, Alexey, Kempf, Harald, Meyer-Hermann, Michael, Arens, Ramon, Kremer, Melanie, Sutter, Gerd, Messerle, Martin, Förster, Reinhold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846978/
https://www.ncbi.nlm.nih.gov/pubmed/26872694
http://dx.doi.org/10.1016/j.immuni.2016.01.010

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