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Assessment of Exposure to VOCs among Pregnant Women in the National Children’s Study

Epidemiologic studies can measure exposure to volatile organic compounds (VOCs) using environmental samples, biomarkers, questionnaires, or observations. These different exposure assessment approaches each have advantages and disadvantages; thus, evaluating relationships is an important consideratio...

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Autores principales: Boyle, Elizabeth Barksdale, Viet, Susan M., Wright, David J., Merrill, Lori S., Alwis, K. Udeni, Blount, Benjamin C., Mortensen, Mary E., Moye, John, Dellarco, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847038/
https://www.ncbi.nlm.nih.gov/pubmed/27043585
http://dx.doi.org/10.3390/ijerph13040376
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author Boyle, Elizabeth Barksdale
Viet, Susan M.
Wright, David J.
Merrill, Lori S.
Alwis, K. Udeni
Blount, Benjamin C.
Mortensen, Mary E.
Moye, John
Dellarco, Michael
author_facet Boyle, Elizabeth Barksdale
Viet, Susan M.
Wright, David J.
Merrill, Lori S.
Alwis, K. Udeni
Blount, Benjamin C.
Mortensen, Mary E.
Moye, John
Dellarco, Michael
author_sort Boyle, Elizabeth Barksdale
collection PubMed
description Epidemiologic studies can measure exposure to volatile organic compounds (VOCs) using environmental samples, biomarkers, questionnaires, or observations. These different exposure assessment approaches each have advantages and disadvantages; thus, evaluating relationships is an important consideration. In the National Children’s Vanguard Study from 2009 to 2010, participants completed questionnaires and data collectors observed VOC exposure sources and collected urine samples from 488 third trimester pregnant women at in-person study visits. From urine, we simultaneously quantified 28 VOC metabolites of exposure to acrolein, acrylamide, acrylonitrile, benzene, 1-bromopropane, 1,3-butadiene, carbon disulfide, crotonaldehyde, cyanide, N,N-dimethylformamide, ethylbenzene, ethylene oxide, propylene oxide, styrene, tetrachloroethylene, toluene, trichloroethylene, vinyl chloride, and xylene exposures using ultra high performance liquid chromatography coupled with an electrospray ionization tandem mass spectrometry (UPLC-ESI/MSMS) method. Urinary thiocyanate was measured using an ion chromatography coupled with an electrospray ionization tandem mass spectrometry method (IC-ESI/MSMS). We modeled the relationship between urinary VOC metabolite concentrations and sources of VOC exposure. Sources of exposure were assessed by participant report via questionnaire (use of air fresheners, aerosols, paint or varnish, organic solvents, and passive/active smoking) and by observations by a trained data collector (presence of scented products in homes). We found several significant (p < 0.01) relationships between the urinary metabolites of VOCs and sources of VOC exposure. Smoking was positively associated with metabolites of the tobacco constituents acrolein, acrylamide, acrylonitrile, 1,3-butadiene, crotonaldehyde, cyanide, ethylene oxide, N,N-dimethylformamide, propylene oxide, styrene, and xylene. Study location was negatively associated with the toluene metabolite N-acetyl-S-(benzyl)-l-cysteine (BMA), and paint use was positively associated with the xylene metabolites 2-methylhippuric acid (2MHA) and 3-Methylhippuric acid & 4-methylhippuric acid (3MHA + 4MHA). A near-significant (p = 0.06) relationship was observed between acrylamide metabolites and observation of incense.
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spelling pubmed-48470382016-05-04 Assessment of Exposure to VOCs among Pregnant Women in the National Children’s Study Boyle, Elizabeth Barksdale Viet, Susan M. Wright, David J. Merrill, Lori S. Alwis, K. Udeni Blount, Benjamin C. Mortensen, Mary E. Moye, John Dellarco, Michael Int J Environ Res Public Health Article Epidemiologic studies can measure exposure to volatile organic compounds (VOCs) using environmental samples, biomarkers, questionnaires, or observations. These different exposure assessment approaches each have advantages and disadvantages; thus, evaluating relationships is an important consideration. In the National Children’s Vanguard Study from 2009 to 2010, participants completed questionnaires and data collectors observed VOC exposure sources and collected urine samples from 488 third trimester pregnant women at in-person study visits. From urine, we simultaneously quantified 28 VOC metabolites of exposure to acrolein, acrylamide, acrylonitrile, benzene, 1-bromopropane, 1,3-butadiene, carbon disulfide, crotonaldehyde, cyanide, N,N-dimethylformamide, ethylbenzene, ethylene oxide, propylene oxide, styrene, tetrachloroethylene, toluene, trichloroethylene, vinyl chloride, and xylene exposures using ultra high performance liquid chromatography coupled with an electrospray ionization tandem mass spectrometry (UPLC-ESI/MSMS) method. Urinary thiocyanate was measured using an ion chromatography coupled with an electrospray ionization tandem mass spectrometry method (IC-ESI/MSMS). We modeled the relationship between urinary VOC metabolite concentrations and sources of VOC exposure. Sources of exposure were assessed by participant report via questionnaire (use of air fresheners, aerosols, paint or varnish, organic solvents, and passive/active smoking) and by observations by a trained data collector (presence of scented products in homes). We found several significant (p < 0.01) relationships between the urinary metabolites of VOCs and sources of VOC exposure. Smoking was positively associated with metabolites of the tobacco constituents acrolein, acrylamide, acrylonitrile, 1,3-butadiene, crotonaldehyde, cyanide, ethylene oxide, N,N-dimethylformamide, propylene oxide, styrene, and xylene. Study location was negatively associated with the toluene metabolite N-acetyl-S-(benzyl)-l-cysteine (BMA), and paint use was positively associated with the xylene metabolites 2-methylhippuric acid (2MHA) and 3-Methylhippuric acid & 4-methylhippuric acid (3MHA + 4MHA). A near-significant (p = 0.06) relationship was observed between acrylamide metabolites and observation of incense. MDPI 2016-03-29 2016-04 /pmc/articles/PMC4847038/ /pubmed/27043585 http://dx.doi.org/10.3390/ijerph13040376 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Boyle, Elizabeth Barksdale
Viet, Susan M.
Wright, David J.
Merrill, Lori S.
Alwis, K. Udeni
Blount, Benjamin C.
Mortensen, Mary E.
Moye, John
Dellarco, Michael
Assessment of Exposure to VOCs among Pregnant Women in the National Children’s Study
title Assessment of Exposure to VOCs among Pregnant Women in the National Children’s Study
title_full Assessment of Exposure to VOCs among Pregnant Women in the National Children’s Study
title_fullStr Assessment of Exposure to VOCs among Pregnant Women in the National Children’s Study
title_full_unstemmed Assessment of Exposure to VOCs among Pregnant Women in the National Children’s Study
title_short Assessment of Exposure to VOCs among Pregnant Women in the National Children’s Study
title_sort assessment of exposure to vocs among pregnant women in the national children’s study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847038/
https://www.ncbi.nlm.nih.gov/pubmed/27043585
http://dx.doi.org/10.3390/ijerph13040376
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