Cargando…
A Toxicological Framework for the Prioritization of Children’s Safe Product Act Data
In response to concerns over hazardous chemicals in children’s products, Washington State passed the Children’s Safe Product Act (CSPA). CSPA requires manufacturers to report the concentration of 66 chemicals in children’s products. We describe a framework for the toxicological prioritization of the...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847093/ https://www.ncbi.nlm.nih.gov/pubmed/27104547 http://dx.doi.org/10.3390/ijerph13040431 |
_version_ | 1782429146426638336 |
---|---|
author | Smith, Marissa N. Grice, Joshua Cullen, Alison Faustman, Elaine M. |
author_facet | Smith, Marissa N. Grice, Joshua Cullen, Alison Faustman, Elaine M. |
author_sort | Smith, Marissa N. |
collection | PubMed |
description | In response to concerns over hazardous chemicals in children’s products, Washington State passed the Children’s Safe Product Act (CSPA). CSPA requires manufacturers to report the concentration of 66 chemicals in children’s products. We describe a framework for the toxicological prioritization of the ten chemical groups most frequently reported under CSPA. The framework scores lifestage, exposure duration, primary, secondary and tertiary exposure routes, toxicokinetics and chemical properties to calculate an exposure score. Four toxicological endpoints were assessed based on curated national and international databases: reproductive and developmental toxicity, endocrine disruption, neurotoxicity and carcinogenicity. A total priority index was calculated from the product of the toxicity and exposure scores. The three highest priority chemicals were formaldehyde, dibutyl phthalate and styrene. Elements of the framework were compared to existing prioritization tools, such as the United States Environmental Protection Agency’s (EPA) ExpoCast and Toxicological Prioritization Index (ToxPi). The CSPA framework allowed us to examine toxicity and exposure pathways in a lifestage-specific manner, providing a relatively high throughput approach to prioritizing hazardous chemicals found in children’s products. |
format | Online Article Text |
id | pubmed-4847093 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-48470932016-05-04 A Toxicological Framework for the Prioritization of Children’s Safe Product Act Data Smith, Marissa N. Grice, Joshua Cullen, Alison Faustman, Elaine M. Int J Environ Res Public Health Article In response to concerns over hazardous chemicals in children’s products, Washington State passed the Children’s Safe Product Act (CSPA). CSPA requires manufacturers to report the concentration of 66 chemicals in children’s products. We describe a framework for the toxicological prioritization of the ten chemical groups most frequently reported under CSPA. The framework scores lifestage, exposure duration, primary, secondary and tertiary exposure routes, toxicokinetics and chemical properties to calculate an exposure score. Four toxicological endpoints were assessed based on curated national and international databases: reproductive and developmental toxicity, endocrine disruption, neurotoxicity and carcinogenicity. A total priority index was calculated from the product of the toxicity and exposure scores. The three highest priority chemicals were formaldehyde, dibutyl phthalate and styrene. Elements of the framework were compared to existing prioritization tools, such as the United States Environmental Protection Agency’s (EPA) ExpoCast and Toxicological Prioritization Index (ToxPi). The CSPA framework allowed us to examine toxicity and exposure pathways in a lifestage-specific manner, providing a relatively high throughput approach to prioritizing hazardous chemicals found in children’s products. MDPI 2016-04-19 2016-04 /pmc/articles/PMC4847093/ /pubmed/27104547 http://dx.doi.org/10.3390/ijerph13040431 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Smith, Marissa N. Grice, Joshua Cullen, Alison Faustman, Elaine M. A Toxicological Framework for the Prioritization of Children’s Safe Product Act Data |
title | A Toxicological Framework for the Prioritization of Children’s Safe Product Act Data |
title_full | A Toxicological Framework for the Prioritization of Children’s Safe Product Act Data |
title_fullStr | A Toxicological Framework for the Prioritization of Children’s Safe Product Act Data |
title_full_unstemmed | A Toxicological Framework for the Prioritization of Children’s Safe Product Act Data |
title_short | A Toxicological Framework for the Prioritization of Children’s Safe Product Act Data |
title_sort | toxicological framework for the prioritization of children’s safe product act data |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847093/ https://www.ncbi.nlm.nih.gov/pubmed/27104547 http://dx.doi.org/10.3390/ijerph13040431 |
work_keys_str_mv | AT smithmarissan atoxicologicalframeworkfortheprioritizationofchildrenssafeproductactdata AT gricejoshua atoxicologicalframeworkfortheprioritizationofchildrenssafeproductactdata AT cullenalison atoxicologicalframeworkfortheprioritizationofchildrenssafeproductactdata AT faustmanelainem atoxicologicalframeworkfortheprioritizationofchildrenssafeproductactdata AT smithmarissan toxicologicalframeworkfortheprioritizationofchildrenssafeproductactdata AT gricejoshua toxicologicalframeworkfortheprioritizationofchildrenssafeproductactdata AT cullenalison toxicologicalframeworkfortheprioritizationofchildrenssafeproductactdata AT faustmanelainem toxicologicalframeworkfortheprioritizationofchildrenssafeproductactdata |