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A Toxicological Framework for the Prioritization of Children’s Safe Product Act Data

In response to concerns over hazardous chemicals in children’s products, Washington State passed the Children’s Safe Product Act (CSPA). CSPA requires manufacturers to report the concentration of 66 chemicals in children’s products. We describe a framework for the toxicological prioritization of the...

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Autores principales: Smith, Marissa N., Grice, Joshua, Cullen, Alison, Faustman, Elaine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847093/
https://www.ncbi.nlm.nih.gov/pubmed/27104547
http://dx.doi.org/10.3390/ijerph13040431
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author Smith, Marissa N.
Grice, Joshua
Cullen, Alison
Faustman, Elaine M.
author_facet Smith, Marissa N.
Grice, Joshua
Cullen, Alison
Faustman, Elaine M.
author_sort Smith, Marissa N.
collection PubMed
description In response to concerns over hazardous chemicals in children’s products, Washington State passed the Children’s Safe Product Act (CSPA). CSPA requires manufacturers to report the concentration of 66 chemicals in children’s products. We describe a framework for the toxicological prioritization of the ten chemical groups most frequently reported under CSPA. The framework scores lifestage, exposure duration, primary, secondary and tertiary exposure routes, toxicokinetics and chemical properties to calculate an exposure score. Four toxicological endpoints were assessed based on curated national and international databases: reproductive and developmental toxicity, endocrine disruption, neurotoxicity and carcinogenicity. A total priority index was calculated from the product of the toxicity and exposure scores. The three highest priority chemicals were formaldehyde, dibutyl phthalate and styrene. Elements of the framework were compared to existing prioritization tools, such as the United States Environmental Protection Agency’s (EPA) ExpoCast and Toxicological Prioritization Index (ToxPi). The CSPA framework allowed us to examine toxicity and exposure pathways in a lifestage-specific manner, providing a relatively high throughput approach to prioritizing hazardous chemicals found in children’s products.
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spelling pubmed-48470932016-05-04 A Toxicological Framework for the Prioritization of Children’s Safe Product Act Data Smith, Marissa N. Grice, Joshua Cullen, Alison Faustman, Elaine M. Int J Environ Res Public Health Article In response to concerns over hazardous chemicals in children’s products, Washington State passed the Children’s Safe Product Act (CSPA). CSPA requires manufacturers to report the concentration of 66 chemicals in children’s products. We describe a framework for the toxicological prioritization of the ten chemical groups most frequently reported under CSPA. The framework scores lifestage, exposure duration, primary, secondary and tertiary exposure routes, toxicokinetics and chemical properties to calculate an exposure score. Four toxicological endpoints were assessed based on curated national and international databases: reproductive and developmental toxicity, endocrine disruption, neurotoxicity and carcinogenicity. A total priority index was calculated from the product of the toxicity and exposure scores. The three highest priority chemicals were formaldehyde, dibutyl phthalate and styrene. Elements of the framework were compared to existing prioritization tools, such as the United States Environmental Protection Agency’s (EPA) ExpoCast and Toxicological Prioritization Index (ToxPi). The CSPA framework allowed us to examine toxicity and exposure pathways in a lifestage-specific manner, providing a relatively high throughput approach to prioritizing hazardous chemicals found in children’s products. MDPI 2016-04-19 2016-04 /pmc/articles/PMC4847093/ /pubmed/27104547 http://dx.doi.org/10.3390/ijerph13040431 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Smith, Marissa N.
Grice, Joshua
Cullen, Alison
Faustman, Elaine M.
A Toxicological Framework for the Prioritization of Children’s Safe Product Act Data
title A Toxicological Framework for the Prioritization of Children’s Safe Product Act Data
title_full A Toxicological Framework for the Prioritization of Children’s Safe Product Act Data
title_fullStr A Toxicological Framework for the Prioritization of Children’s Safe Product Act Data
title_full_unstemmed A Toxicological Framework for the Prioritization of Children’s Safe Product Act Data
title_short A Toxicological Framework for the Prioritization of Children’s Safe Product Act Data
title_sort toxicological framework for the prioritization of children’s safe product act data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847093/
https://www.ncbi.nlm.nih.gov/pubmed/27104547
http://dx.doi.org/10.3390/ijerph13040431
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