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Investigations on recyclisation and hydrolysis in avibactam mediated serine β-lactamase inhibition

β-Lactams inhibit penicillin-binding proteins (PBPs) and serine β-lactamases by acylation of a nucleophilic active site serine. Avibactam is approved for clinical use in combination with ceftazidime, and is a breakthrough non β-lactam β-lactamase inhibitor also reacting via serine acylation. Molecul...

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Detalles Bibliográficos
Autores principales:	Choi, Hwanho, Paton, Robert S., Park, Hwangseo, Schofield, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2016
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847122/ https://www.ncbi.nlm.nih.gov/pubmed/27072755 http://dx.doi.org/10.1039/c6ob00353b

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