Cargando…

Atractylenolide I modulates ovarian cancer cell-mediated immunosuppression by blocking MD-2/TLR4 complex-mediated MyD88/NF-κB signaling in vitro

BACKGROUND: TLR4/MD-2 complex-mediated MyD88-dependent activation of NF-κB and Akt promotes tumor-associated immunosuppression in epithelial ovarian cancer (EOC) via induction of immunesuppressive cytokines and indoleamine 2,3-dioxygenase (IDO). Atractylenolide I (AO-1) is a naturally occurring sesq...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Hong, Zhang, Guonan, Huang, Jianming, Ma, Shiqi, Mi, Kun, Cheng, Jia, Zhu, Yi, Zha, Xiao, Huang, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847224/ https://www.ncbi.nlm.nih.gov/pubmed/27118139 http://dx.doi.org/10.1186/s12967-016-0845-5

Ejemplares similares

Atractylenolide-I Sensitizes Human Ovarian Cancer Cells to Paclitaxel by Blocking Activation of TLR4/MyD88-dependent Pathway
por: Huang, Jian-Ming, et al.
Publicado: (2014)

The TLR4-MyD88-NF-κB pathway is involved in sIgA-mediated IgA nephropathy
por: Zhang, Junjun, et al.
Publicado: (2020)

The Effect of TLR9, MyD88, and NF-κB p65 in Systemic Lupus Erythematosus
por: Wang, Huanan, et al.
Publicado: (2022)

Soyasaponins reduce inflammation by downregulating MyD88 expression and suppressing the recruitments of TLR4 and MyD88 into lipid rafts
por: Chen, Junbin, et al.
Publicado: (2020)

Expression of TLR4-MyD88 and NF-κB in the Iris during Endotoxin-Induced Uveitis
por: Li, Shang, et al.
Publicado: (2010)

Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-κB signaling pathway
por: Li, Chengcheng, et al.
Publicado: (2017)

The role of TLR4/MyD88/NF‐κB pathway in periodontitis‐induced liver inflammation of rats
por: Yue, Yiyun, et al.
Publicado: (2020)

Mechanism of MyD88S mediated signal termination
por: Pustelny, Katarzyna, et al.
Publicado: (2022)

TLR/MyD88-mediated Innate Immunity in Intestinal Graft-versus-Host Disease
por: Lee, Young-Kwan, et al.
Publicado: (2017)

Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88
por: Sakai, Jiro, et al.
Publicado: (2017)

Oxymatrine Downregulates TLR4, TLR2, MyD88, and NF-κB and Protects Rat Brains against Focal Ischemia
por: Fan, Hongguang, et al.
Publicado: (2009)

Exercise Therapy Downregulates the Overexpression of TLR4, TLR2, MyD88 and NF-κB after Cerebral Ischemia in Rats
por: Ma, Yuewen, et al.
Publicado: (2013)

FoxO1 regulates TLR4/MyD88/MD2‐NF‐κB inflammatory signalling in mucosal barrier injury of inflammatory bowel disease
por: Han, Chenyang, et al.
Publicado: (2020)

Baishouwu Extract Suppresses the Development of Hepatocellular Carcinoma via TLR4/MyD88/NF-κB Pathway
por: Ding, Yong-fang, et al.
Publicado: (2019)

Lipoxin suppresses inflammation via the TLR4/MyD88/NF‐κB pathway in periodontal ligament cells
por: Ali, Muhanad, et al.
Publicado: (2019)

Tacrolimus alleviates LPS‐induced AKI by inhibiting TLR4/MyD88/NF‐κB signalling in mice
por: Hu, Xueqing, et al.
Publicado: (2021)

Acupuncture Attenuates Inflammation in Microglia of Vascular Dementia Rats by Inhibiting miR-93-Mediated TLR4/MyD88/NF-κB Signaling Pathway
por: Wang, Lu, et al.
Publicado: (2020)

MyD88 deficiency aggravates the severity of acute pancreatitis by promoting MyD88-independent TRIF pathway-mediated necrosis
por: Yang, Du-Jiang, et al.
Publicado: (2022)

Rapamycin improves sevoflurane-induced cognitive dysfunction in aged rats by mediating autophagy through the TLR4/MyD88/NF-κB signaling pathway
por: Li, Yan, et al.
Publicado: (2019)

MyD88 and TLR4 Expression in Epithelial Ovarian Cancer
por: Block, Matthew S., et al.
Publicado: (2018)

Inflammatory Role of TLR-MyD88 Signaling in Multiple Sclerosis
por: Zheng, Chao, et al.
Publicado: (2020)

Vinpocetine alleviate cerebral ischemia/reperfusion injury by down-regulating TLR4/MyD88/NF-κB signaling
por: Wu, Li-Rong, et al.
Publicado: (2017)

Dexmedetomidine Protects Cardiomyocytes against Hypoxia/Reoxygenation Injury by Suppressing TLR4-MyD88-NF-κB Signaling
por: Gao, Jin-meng, et al.
Publicado: (2017)

LIGHT aggravates sepsis‐associated acute kidney injury via TLR4‐MyD88‐NF‐κB pathway
por: Zhong, Yu, et al.
Publicado: (2020)

Exercise Training Attenuates Hypertension Through TLR4/MyD88/NF-κB Signaling in the Hypothalamic Paraventricular Nucleus
por: Qi, Jie, et al.
Publicado: (2019)

Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo
por: Dutta, Debashis, et al.
Publicado: (2021)

MyD88 mediates colorectal cancer cell proliferation, migration and invasion via NF-κB/AP-1 signaling pathway
por: Zhu, Guangwei, et al.
Publicado: (2020)

Baicalin Mitigates the Neuroinflammation through the TLR4/MyD88/NF-κB and MAPK Pathways in LPS-Stimulated BV-2 Microglia
por: Li, Baojing, et al.
Publicado: (2022)

TLR2 and TLR4 Mediate Differential Responses to Limb Ischemia through MyD88-Dependent and Independent Pathways
por: Sachdev, Ulka, et al.
Publicado: (2012)

Pterostilbene reduces endothelial cell apoptosis by regulation of the Nrf2-mediated TLR-4/MyD88/NF-κB pathway in a rat model of atherosclerosis
por: Xiong, Xiaowei, et al.
Publicado: (2020)

Vitamin D Protects against Traumatic Brain Injury via Modulating TLR4/MyD88/NF-κB Pathway-Mediated Microglial Polarization and Neuroinflammation
por: Jiang, Hongsheng, et al.
Publicado: (2022)

Adjuvant Efficacy of the ECMS-Oil on Immune Responses against Bordetella bronchiseptica in Mice through the TLR2/MyD88/NF-κB Pathway
por: Xiao, Chenwen, et al.
Publicado: (2023)

TLR4/MyD88 -mediated CCL2 production by lipopolysaccharide (endotoxin): Implications for metabolic inflammation
por: Akhter, Nadeem, et al.
Publicado: (2018)

MyD88 Mediates Colitis- and RANKL-Induced Microfold Cell Differentiation
por: Li, Yang, et al.
Publicado: (2021)

A TIR Domain Protein from E. faecalis Attenuates MyD88-Mediated Signaling and NF-κB Activation
por: Zou, Jun, et al.
Publicado: (2014)

Isovitexin alleviates acute gouty arthritis in rats by inhibiting inflammation via the TLR4/MyD88/NF-κB pathway
por: Sun, Xiujiang, et al.
Publicado: (2021)

l-Isoleucine Administration Alleviates DSS-Induced Colitis by Regulating TLR4/MyD88/NF-κB Pathway in Rats
por: Mao, Xiangbing, et al.
Publicado: (2022)

Inhibition of Mogroside IIIE on isoproterenol-induced myocardial fibrosis through the TLR4/MyD88/NF-κB signaling pathway
por: Yanan, Shi, et al.
Publicado: (2023)

From monogenic lupus to TLR7/MyD88-targeted therapy
por: Wang, Min, et al.
Publicado: (2022)

Hyperbaric Oxygen Therapy Alleviates Paclitaxel-Induced Peripheral Neuropathy Involving Suppressing TLR4-MyD88-NF-κB Signaling Pathway
por: Wang, Shih-Hung, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_kuh5101f8301pdrbq1k7jr83vr