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Malaria, helminths and malnutrition: a cross-sectional survey of school children in the South-Tongu district of Ghana

BACKGROUND: As part of malaria characterization study in the South-Tongu district of Ghana, the current study was conducted to explore relationships between malaria, schistosomiasis, soil transmitted helminths and malnutrition in riparian community settings that had hitherto encountered episodes of...

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Autores principales: Ayeh-Kumi, Patrick Ferdinand, Addo-Osafo, Kantanka, Attah, Simon Kwaku, Tetteh-Quarcoo, Patience Borkor, Obeng-Nkrumah, Noah, Awuah-Mensah, Georgina, Abbey, Harriet Naa Afia, Forson, Akua, Cham, Momodou, Asare, Listowell, Duedu, Kwabena Obeng, Asmah, Richard Harry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847346/
https://www.ncbi.nlm.nih.gov/pubmed/27118136
http://dx.doi.org/10.1186/s13104-016-2025-3
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author Ayeh-Kumi, Patrick Ferdinand
Addo-Osafo, Kantanka
Attah, Simon Kwaku
Tetteh-Quarcoo, Patience Borkor
Obeng-Nkrumah, Noah
Awuah-Mensah, Georgina
Abbey, Harriet Naa Afia
Forson, Akua
Cham, Momodou
Asare, Listowell
Duedu, Kwabena Obeng
Asmah, Richard Harry
author_facet Ayeh-Kumi, Patrick Ferdinand
Addo-Osafo, Kantanka
Attah, Simon Kwaku
Tetteh-Quarcoo, Patience Borkor
Obeng-Nkrumah, Noah
Awuah-Mensah, Georgina
Abbey, Harriet Naa Afia
Forson, Akua
Cham, Momodou
Asare, Listowell
Duedu, Kwabena Obeng
Asmah, Richard Harry
author_sort Ayeh-Kumi, Patrick Ferdinand
collection PubMed
description BACKGROUND: As part of malaria characterization study in the South-Tongu district of Ghana, the current study was conducted to explore relationships between malaria, schistosomiasis, soil transmitted helminths and malnutrition in riparian community settings that had hitherto encountered episodes of mass deworming exercises. METHODS: School-age children were enrolled in a cross-sectional study from April through July 2012. Stool and urine samples were examined respectively for helminths and Schistosoma haematobium. Blood samples were analyzed for malaria parasites and haemoglobin (Hb) concentrations, respectively. Anthropometric indices were measured. Relationships were determined using generalized linear models. RESULTS: The results show low numbers of asymptomatic Plasmodium falciparum (9.2 %, n = 37/404) and S. haematobium (2.5 %, n = 10/404) infections. The associations between significance terms in the multivariate analysis for P. falciparum infections were further assessed to test the significance of the product terms directly i.e., age in years [adjusted odds ratio (AOR), 3.1; 95 % confidence interval (CI) 1.1–5.6], Hb concentration (AOR = 0.71; 95 % CI 0.42–2.3), and stunted malnutrition (AOR, 8.72; 95 % CI 4.8–25.1). The P. falciparum-associated decrease in mean Hb concentration was 2.82 g/dl (95 % CI 1.63–4.1 g/dl; P = 0.001) in stunted children, and 0.75 g/dl (95 % CI 1.59–0.085 g/dl; P = 0.076) in the non-stunted cohort. The anaemia-associated decrease in mean parasitaemia in stunted children was 3500 parasites/µl of blood (95 % CI 262.46–6737.54 parasites/µl of blood; P = 0.036), and in non-stunted children 2127 parasites/µl of blood (95 % CI −0.27 to 4.53; P = 0.085). Stunted malnutrition was the strongest predictor of S. haematobium infection (AOR = 11; 95 % CI 3.1–33.6) but significant associations as described for P. falciparum infections were absent. The population attributable risk of anaemia due to P. falciparum was 6.3 % (95 % CI 2.5–9.3), 0.9 % (95 % CI 0.4–2.3) for S. haematobium, and 12.5 % (95 % CI 9.11–19.52) for stunted malnutrition. CONCLUSION: Plasmodium falciparum, S. haematobium, intestinal helminths and their co-infections were uncommon in our school-age children. Stunting exacerbated the extent to which malaria was associated with loss in Hb concentration. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13104-016-2025-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-48473462016-04-28 Malaria, helminths and malnutrition: a cross-sectional survey of school children in the South-Tongu district of Ghana Ayeh-Kumi, Patrick Ferdinand Addo-Osafo, Kantanka Attah, Simon Kwaku Tetteh-Quarcoo, Patience Borkor Obeng-Nkrumah, Noah Awuah-Mensah, Georgina Abbey, Harriet Naa Afia Forson, Akua Cham, Momodou Asare, Listowell Duedu, Kwabena Obeng Asmah, Richard Harry BMC Res Notes Research Article BACKGROUND: As part of malaria characterization study in the South-Tongu district of Ghana, the current study was conducted to explore relationships between malaria, schistosomiasis, soil transmitted helminths and malnutrition in riparian community settings that had hitherto encountered episodes of mass deworming exercises. METHODS: School-age children were enrolled in a cross-sectional study from April through July 2012. Stool and urine samples were examined respectively for helminths and Schistosoma haematobium. Blood samples were analyzed for malaria parasites and haemoglobin (Hb) concentrations, respectively. Anthropometric indices were measured. Relationships were determined using generalized linear models. RESULTS: The results show low numbers of asymptomatic Plasmodium falciparum (9.2 %, n = 37/404) and S. haematobium (2.5 %, n = 10/404) infections. The associations between significance terms in the multivariate analysis for P. falciparum infections were further assessed to test the significance of the product terms directly i.e., age in years [adjusted odds ratio (AOR), 3.1; 95 % confidence interval (CI) 1.1–5.6], Hb concentration (AOR = 0.71; 95 % CI 0.42–2.3), and stunted malnutrition (AOR, 8.72; 95 % CI 4.8–25.1). The P. falciparum-associated decrease in mean Hb concentration was 2.82 g/dl (95 % CI 1.63–4.1 g/dl; P = 0.001) in stunted children, and 0.75 g/dl (95 % CI 1.59–0.085 g/dl; P = 0.076) in the non-stunted cohort. The anaemia-associated decrease in mean parasitaemia in stunted children was 3500 parasites/µl of blood (95 % CI 262.46–6737.54 parasites/µl of blood; P = 0.036), and in non-stunted children 2127 parasites/µl of blood (95 % CI −0.27 to 4.53; P = 0.085). Stunted malnutrition was the strongest predictor of S. haematobium infection (AOR = 11; 95 % CI 3.1–33.6) but significant associations as described for P. falciparum infections were absent. The population attributable risk of anaemia due to P. falciparum was 6.3 % (95 % CI 2.5–9.3), 0.9 % (95 % CI 0.4–2.3) for S. haematobium, and 12.5 % (95 % CI 9.11–19.52) for stunted malnutrition. CONCLUSION: Plasmodium falciparum, S. haematobium, intestinal helminths and their co-infections were uncommon in our school-age children. Stunting exacerbated the extent to which malaria was associated with loss in Hb concentration. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13104-016-2025-3) contains supplementary material, which is available to authorized users. BioMed Central 2016-04-27 /pmc/articles/PMC4847346/ /pubmed/27118136 http://dx.doi.org/10.1186/s13104-016-2025-3 Text en © Ayeh-Kumi et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Ayeh-Kumi, Patrick Ferdinand
Addo-Osafo, Kantanka
Attah, Simon Kwaku
Tetteh-Quarcoo, Patience Borkor
Obeng-Nkrumah, Noah
Awuah-Mensah, Georgina
Abbey, Harriet Naa Afia
Forson, Akua
Cham, Momodou
Asare, Listowell
Duedu, Kwabena Obeng
Asmah, Richard Harry
Malaria, helminths and malnutrition: a cross-sectional survey of school children in the South-Tongu district of Ghana
title Malaria, helminths and malnutrition: a cross-sectional survey of school children in the South-Tongu district of Ghana
title_full Malaria, helminths and malnutrition: a cross-sectional survey of school children in the South-Tongu district of Ghana
title_fullStr Malaria, helminths and malnutrition: a cross-sectional survey of school children in the South-Tongu district of Ghana
title_full_unstemmed Malaria, helminths and malnutrition: a cross-sectional survey of school children in the South-Tongu district of Ghana
title_short Malaria, helminths and malnutrition: a cross-sectional survey of school children in the South-Tongu district of Ghana
title_sort malaria, helminths and malnutrition: a cross-sectional survey of school children in the south-tongu district of ghana
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847346/
https://www.ncbi.nlm.nih.gov/pubmed/27118136
http://dx.doi.org/10.1186/s13104-016-2025-3
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