Recent advances in understanding Kaposi’s sarcoma-associated herpesvirus

Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV) is an oncogenic human herpesvirus. KSHV is associated with three cancers in the human population: KS, primary effusion lymphoma (PEL), and multicentric Castleman’s disease (MCD). KS is the leading cause of cancer in HIV-infected individuals. In thi...

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Detalles Bibliográficos
Autores principales: Dissinger, Nathan J., Damania, Blossom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847565/
https://www.ncbi.nlm.nih.gov/pubmed/27158465
http://dx.doi.org/10.12688/f1000research.7612.1
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author Dissinger, Nathan J.
Damania, Blossom
author_facet Dissinger, Nathan J.
Damania, Blossom
author_sort Dissinger, Nathan J.
collection PubMed
description Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV) is an oncogenic human herpesvirus. KSHV is associated with three cancers in the human population: KS, primary effusion lymphoma (PEL), and multicentric Castleman’s disease (MCD). KS is the leading cause of cancer in HIV-infected individuals. In this review, we discuss the most recent discoveries behind the mechanisms of KSHV latency maintenance and lytic replication. We also review current therapies for KSHV-associated cancers.
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spelling pubmed-48475652016-05-06 Recent advances in understanding Kaposi’s sarcoma-associated herpesvirus Dissinger, Nathan J. Damania, Blossom F1000Res Review Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV) is an oncogenic human herpesvirus. KSHV is associated with three cancers in the human population: KS, primary effusion lymphoma (PEL), and multicentric Castleman’s disease (MCD). KS is the leading cause of cancer in HIV-infected individuals. In this review, we discuss the most recent discoveries behind the mechanisms of KSHV latency maintenance and lytic replication. We also review current therapies for KSHV-associated cancers. F1000Research 2016-04-25 /pmc/articles/PMC4847565/ /pubmed/27158465 http://dx.doi.org/10.12688/f1000research.7612.1 Text en Copyright: © 2016 Dissinger NJ and Damania B http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Dissinger, Nathan J.
Damania, Blossom
Recent advances in understanding Kaposi’s sarcoma-associated herpesvirus
title Recent advances in understanding Kaposi’s sarcoma-associated herpesvirus
title_full Recent advances in understanding Kaposi’s sarcoma-associated herpesvirus
title_fullStr Recent advances in understanding Kaposi’s sarcoma-associated herpesvirus
title_full_unstemmed Recent advances in understanding Kaposi’s sarcoma-associated herpesvirus
title_short Recent advances in understanding Kaposi’s sarcoma-associated herpesvirus
title_sort recent advances in understanding kaposi’s sarcoma-associated herpesvirus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847565/
https://www.ncbi.nlm.nih.gov/pubmed/27158465
http://dx.doi.org/10.12688/f1000research.7612.1
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