Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase

Heparanase is a β-d-glucuronidase which cleaves heparan sulfate chains in the extracellular matrix and on cellular membranes. A dysregulated heparanase activity is intimately associated with cell invasion, tumor metastasis and angiogenesis, making heparanase an attractive target for the development...

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Detalles Bibliográficos
Autores principales: Pala, Daniele, Rivara, Silvia, Mor, Marco, Milazzo, Ferdinando Maria, Roscilli, Giuseppe, Pavoni, Emiliano, Giannini, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847616/
https://www.ncbi.nlm.nih.gov/pubmed/26762172
http://dx.doi.org/10.1093/glycob/cww003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847616/
https://www.ncbi.nlm.nih.gov/pubmed/26762172
http://dx.doi.org/10.1093/glycob/cww003

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