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Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase
Heparanase is a β-d-glucuronidase which cleaves heparan sulfate chains in the extracellular matrix and on cellular membranes. A dysregulated heparanase activity is intimately associated with cell invasion, tumor metastasis and angiogenesis, making heparanase an attractive target for the development...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847616/ https://www.ncbi.nlm.nih.gov/pubmed/26762172 http://dx.doi.org/10.1093/glycob/cww003 |