Cargando…

Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV

Monitoring the efficacy of novel reservoir-reducing treatments for HIV is challenging. The limited ability to sample and quantify latent infection means that supervised antiretroviral therapy (ART) interruption studies are generally required. Here we introduce a set of mathematical and statistical m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hill, Alison L., Rosenbloom, Daniel I. S., Goldstein, Edward, Hanhauser, Emily, Kuritzkes, Daniel R., Siliciano, Robert F., Henrich, Timothy J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847932/ https://www.ncbi.nlm.nih.gov/pubmed/27119536 http://dx.doi.org/10.1371/journal.ppat.1005535

Ejemplares similares

Correction: Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV
por: Hill, Alison L., et al.
Publicado: (2017)

Correction: Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV
Publicado: (2016)

Impact of HLA Class I Alleles on Timing of HIV Rebound After Antiretroviral Treatment Interruption
por: Park, You Jeong, et al.
Publicado: (2017)

Designing and Interpreting Limiting Dilution Assays: General Principles and Applications to the Latent Reservoir for Human Immunodeficiency Virus-1
por: Rosenbloom, Daniel I. S., et al.
Publicado: (2015)

Episomal Viral cDNAs Identify a Reservoir That Fuels Viral Rebound after Treatment Interruption and That Contributes to Treatment Failure
por: Sharkey, Mark, et al.
Publicado: (2011)

Insufficient Evidence for Rare Activation of Latent HIV in the Absence of Reservoir-Reducing Interventions
por: Hill, Alison L., et al.
Publicado: (2016)

Antiretroviral dynamics determines HIV evolution and predicts therapy outcome
por: Rosenbloom, Daniel I. S., et al.
Publicado: (2012)

Phospholipid Metabolism Is Associated with Time to HIV Rebound upon Treatment Interruption
por: Giron, Leila B., et al.
Publicado: (2021)

Compartmentalized HIV rebound in the central nervous system after interruption of antiretroviral therapy
por: Gianella, Sara, et al.
Publicado: (2016)

Increased Risk of Virologic Rebound in Patients on Antiviral Therapy with a Detectable HIV Load <48 Copies/mL
por: Henrich, Timothy J., et al.
Publicado: (2012)

Anti-HIV Antibody Responses and the HIV Reservoir Size during Antiretroviral Therapy
por: Lee, Sulggi A., et al.
Publicado: (2016)

Expression of type I interferon-associated genes at antiretroviral therapy interruption predicts HIV virological rebound
por: Zacharopoulou, P., et al.
Publicado: (2022)

Cells producing residual viremia during antiretroviral treatment appear to contribute to rebound viremia following interruption of treatment
por: Aamer, Hadega A., et al.
Publicado: (2020)

Rapid viral rebound after analytical treatment interruption in patients with very small HIV reservoir and minimal on‐going viral transcription
por: Pannus, Pieter, et al.
Publicado: (2020)

Residual Proviral Reservoirs: A High Risk for HIV Persistence and Driving Forces for Viral Rebound after Analytical Treatment Interruption
por: Wang, Xiaolei, et al.
Publicado: (2021)

Transient viral replication during analytical treatment interruptions in SIV infected macaques can alter the rebound-competent viral reservoir
por: Immonen, Taina T., et al.
Publicado: (2021)

Biphasic decay of intact SHIV genomes following initiation of antiretroviral therapy complicates analysis of interventions targeting the reservoir
por: Kumar, Mithra R., et al.
Publicado: (2023)

Nanostructured Optical Photonic Crystal Biosensor for HIV Viral Load Measurement
por: Shafiee, Hadi, et al.
Publicado: (2014)

Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection
por: Colby, Donn, et al.
Publicado: (2018)

Factors affecting the timing of adiposity rebound
por: Koyama, Satomi, et al.
Publicado: (2013)

Early Initiation of Antiretroviral Therapy Following In Utero HIV Infection Is Associated With Low Viral Reservoirs but Other Factors Determine Viral Rebound
por: Millar, Jane R, et al.
Publicado: (2021)

Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy
por: Fennessey, Christine M., et al.
Publicado: (2017)

Insight into treatment of HIV infection from viral dynamics models
por: Hill, Alison L., et al.
Publicado: (2018)

Effect of analytical treatment interruption and reinitiation of antiretroviral therapy on HIV reservoirs and immunologic parameters in infected individuals
por: Clarridge, Katherine E., et al.
Publicado: (2018)

TLR7 agonist, N6-LS and PGT121 delayed viral rebound in SHIV-infected macaques after antiretroviral therapy interruption
por: Hsu, Denise C., et al.
Publicado: (2021)

Impact of antiretroviral therapy in primary HIV infection on natural killer cell function and the association with viral rebound and HIV DNA following treatment interruption
por: Pace, Matthew, et al.
Publicado: (2022)

Proliferation of latently infected CD4(+) T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics
por: Hosmane, Nina N., et al.
Publicado: (2017)

Immunological biomarkers predict HIV-1 viral rebound after treatment interruption
por: Hurst, Jacob, et al.
Publicado: (2015)

Models of SIV rebound after treatment interruption that involve multiple reactivation events
por: van Dorp, Christiaan H., et al.
Publicado: (2020)

The risk of viral rebound in the year after delivery in women remaining on antiretroviral therapy
por: Huntington, Susie, et al.
Publicado: (2015)

High-throughput Characterization of HIV-1 Reservoir Reactivation Using a Single-Cell-in-Droplet PCR Assay
por: Yucha, Robert W., et al.
Publicado: (2017)

To rebound or not to rebound
por: Stahl, Bethany A, et al.
Publicado: (2017)

Increased Proviral DNA in Circulating Cells Correlates with Plasma Viral Rebound in Simian Immunodeficiency Virus-Infected Rhesus Macaques after Antiretroviral Therapy Interruption
por: Ziani, Widade, et al.
Publicado: (2021)

The ethical case for placebo control in HIV-cure-related studies with ART interruption
por: Magalhaes, Monica, et al.
Publicado: (2022)

Printed Flexible Plastic Microchip for Viral Load Measurement through Quantitative Detection of Viruses in Plasma and Saliva
por: Shafiee, Hadi, et al.
Publicado: (2015)

The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy
por: McMyn, Natalie F., et al.
Publicado: (2023)

Assessing intra-lab precision and inter-lab repeatability of outgrowth assays of HIV-1 latent reservoir size
por: Rosenbloom, Daniel I. S., et al.
Publicado: (2019)

Assessing the Suitability of Next-Generation Viral Outgrowth Assays to Measure Human Immunodeficiency Virus 1 Latent Reservoir Size
por: Stone, Mars, et al.
Publicado: (2020)

Real-Time Adherence Monitoring for HIV Antiretroviral Therapy
por: Haberer, Jessica E., et al.
Publicado: (2010)

Sample size and power considerations for ordinary least squares interrupted time series analysis: a simulation study
por: Hawley, Samuel, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_tnd2rsq2l4vn0edqclmmf6ohmn