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Degradation of Gadd45 mRNA by nonsense-mediated decay is essential for viability

The nonsense-mediated mRNA decay (NMD) pathway functions to degrade both abnormal and wild-type mRNAs. NMD is essential for viability in most organisms, but the molecular basis for this requirement is unknown. Here we show that a single, conserved NMD target, the mRNA coding for the stress response...

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Detalles Bibliográficos
Autores principales:	Nelson, Jonathan O, Moore, Kristin A, Chapin, Alex, Hollien, Julie, Metzstein, Mark M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848089/ https://www.ncbi.nlm.nih.gov/pubmed/26952209 http://dx.doi.org/10.7554/eLife.12876

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