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Multidisciplinary rehabilitation and steroids in the management of multiple sclerosis relapses: a randomized controlled trial

INTRODUCTION: Periodic relapses are one of the main characteristics of multiple sclerosis (MS), from which recovery is often incomplete despite high-dose methylprednisolone (HDMP) treatment. The aim of our study was to evaluate the potential benefits of short-term HDMP combined with multidisciplinar...

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Autores principales: Nedeljkovic, Una, Dackovic, Jelena, Tepavcevic, Darija Kisic, Basuroski, Irena Dujmovic, Mesaros, Sarlota, Pekmezovic, Tatjana, Drulovic, Jelena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848347/
https://www.ncbi.nlm.nih.gov/pubmed/27186184
http://dx.doi.org/10.5114/aoms.2015.47289
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author Nedeljkovic, Una
Dackovic, Jelena
Tepavcevic, Darija Kisic
Basuroski, Irena Dujmovic
Mesaros, Sarlota
Pekmezovic, Tatjana
Drulovic, Jelena
author_facet Nedeljkovic, Una
Dackovic, Jelena
Tepavcevic, Darija Kisic
Basuroski, Irena Dujmovic
Mesaros, Sarlota
Pekmezovic, Tatjana
Drulovic, Jelena
author_sort Nedeljkovic, Una
collection PubMed
description INTRODUCTION: Periodic relapses are one of the main characteristics of multiple sclerosis (MS), from which recovery is often incomplete despite high-dose methylprednisolone (HDMP) treatment. The aim of our study was to evaluate the potential benefits of short-term HDMP combined with multidisciplinary rehabilitation (MDR) in persons with MS in relapse in order to assess whether combination of steroid therapy with MDR is more beneficial than steroid therapy alone. MATERIAL AND METHODS: This investigation was conducted as a randomized controlled trial. The MS patients were eligible if they had an established diagnosis and relapse requiring application of HDMP. Forty-nine patients were included in the study and randomized to control and treatment groups, and 37 completed the study. High-dose methylprednisolone was administered to all patients. The treatment group additionally underwent an MDR program over a 3-week period. All outcome measures were completed at baseline and 1 and 3 months later. RESULTS: The Expanded Disability Status Scale (EDSS) and Functional Independence Measure (FIM) motor scores improved statistically significantly 1 month after HDMP, in both treatment and control groups. During the study period, in the treatment group, a sustained large effect size (ES) was found for both physical and mental composite scores of Multiple Sclerosis Quality of Life-54 (MSQoL-54), while in the controls, a sustained moderate ES was demonstrated only for physical composite score. CONCLUSIONS: Our findings suggest that MDR improves MS relapse outcome.
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spelling pubmed-48483472016-05-16 Multidisciplinary rehabilitation and steroids in the management of multiple sclerosis relapses: a randomized controlled trial Nedeljkovic, Una Dackovic, Jelena Tepavcevic, Darija Kisic Basuroski, Irena Dujmovic Mesaros, Sarlota Pekmezovic, Tatjana Drulovic, Jelena Arch Med Sci Clinical Research INTRODUCTION: Periodic relapses are one of the main characteristics of multiple sclerosis (MS), from which recovery is often incomplete despite high-dose methylprednisolone (HDMP) treatment. The aim of our study was to evaluate the potential benefits of short-term HDMP combined with multidisciplinary rehabilitation (MDR) in persons with MS in relapse in order to assess whether combination of steroid therapy with MDR is more beneficial than steroid therapy alone. MATERIAL AND METHODS: This investigation was conducted as a randomized controlled trial. The MS patients were eligible if they had an established diagnosis and relapse requiring application of HDMP. Forty-nine patients were included in the study and randomized to control and treatment groups, and 37 completed the study. High-dose methylprednisolone was administered to all patients. The treatment group additionally underwent an MDR program over a 3-week period. All outcome measures were completed at baseline and 1 and 3 months later. RESULTS: The Expanded Disability Status Scale (EDSS) and Functional Independence Measure (FIM) motor scores improved statistically significantly 1 month after HDMP, in both treatment and control groups. During the study period, in the treatment group, a sustained large effect size (ES) was found for both physical and mental composite scores of Multiple Sclerosis Quality of Life-54 (MSQoL-54), while in the controls, a sustained moderate ES was demonstrated only for physical composite score. CONCLUSIONS: Our findings suggest that MDR improves MS relapse outcome. Termedia Publishing House 2015-03-18 2016-04-01 /pmc/articles/PMC4848347/ /pubmed/27186184 http://dx.doi.org/10.5114/aoms.2015.47289 Text en Copyright © 2015 Termedia & Banach http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Clinical Research
Nedeljkovic, Una
Dackovic, Jelena
Tepavcevic, Darija Kisic
Basuroski, Irena Dujmovic
Mesaros, Sarlota
Pekmezovic, Tatjana
Drulovic, Jelena
Multidisciplinary rehabilitation and steroids in the management of multiple sclerosis relapses: a randomized controlled trial
title Multidisciplinary rehabilitation and steroids in the management of multiple sclerosis relapses: a randomized controlled trial
title_full Multidisciplinary rehabilitation and steroids in the management of multiple sclerosis relapses: a randomized controlled trial
title_fullStr Multidisciplinary rehabilitation and steroids in the management of multiple sclerosis relapses: a randomized controlled trial
title_full_unstemmed Multidisciplinary rehabilitation and steroids in the management of multiple sclerosis relapses: a randomized controlled trial
title_short Multidisciplinary rehabilitation and steroids in the management of multiple sclerosis relapses: a randomized controlled trial
title_sort multidisciplinary rehabilitation and steroids in the management of multiple sclerosis relapses: a randomized controlled trial
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848347/
https://www.ncbi.nlm.nih.gov/pubmed/27186184
http://dx.doi.org/10.5114/aoms.2015.47289
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