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A PARP1-ERK2 synergism is required for the induction of LTP

Unexpectedly, a post-translational modification of DNA-binding proteins, initiating the cell response to single-strand DNA damage, was also required for long-term memory acquisition in a variety of learning paradigms. Our findings disclose a molecular mechanism based on PARP1-Erk synergism, which ma...

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Detalles Bibliográficos
Autores principales: Visochek, L., Grigoryan, G., Kalal, A., Milshtein-Parush, H., Gazit, N., Slutsky, I., Yeheskel, A., Shainberg, A., Castiel, A., Seger, R., Langelier, M. F., Dantzer, F., Pascal, J. M., Segal, M., Cohen-Armon, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848477/
https://www.ncbi.nlm.nih.gov/pubmed/27121568
http://dx.doi.org/10.1038/srep24950