The HSP70 co-chaperone DNAJC14 targets misfolded pendrin for unconventional protein secretion

Mutations in SLC26A4, which encodes pendrin, are responsible for hearing loss with an enlarged vestibular aqueduct and Pendred syndrome. The most prevalent mutation in East Asia is p.H723R (His723Arg), which leads to defects in protein folding and cell-surface expression. Here we show that H723R-pen...

Descripción completa

Detalles Bibliográficos
Autores principales: Jung, Jinsei, Kim, Jiyoon, Roh, Shin Hye, Jun, Ikhyun, Sampson, Robert D., Gee, Heon Yung, Choi, Jae Young, Lee, Min Goo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848490/
https://www.ncbi.nlm.nih.gov/pubmed/27109633
http://dx.doi.org/10.1038/ncomms11386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848490/
https://www.ncbi.nlm.nih.gov/pubmed/27109633
http://dx.doi.org/10.1038/ncomms11386

Ejemplares similares