Retroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration

Retroviruses must integrate their linear viral cDNA into the host genome for a productive infection. Integration is catalysed by the retrovirus-encoded integrase (IN), which forms a tetramer or octamer complex with the viral cDNA long terminal repeat (LTR) ends termed an intasome. IN removes two 3′-...

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Detalles Bibliográficos
Autores principales: Jones, Nathan D., Lopez Jr, Miguel A., Hanne, Jeungphill, Peake, Mitchell B., Lee, Jong-Bong, Fishel, Richard, Yoder, Kristine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848512/
https://www.ncbi.nlm.nih.gov/pubmed/27108531
http://dx.doi.org/10.1038/ncomms11409

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