Dynamics of histone H2A, H4 and HS1ph during spermatogenesis with a focus on chromatin condensation and maturity of spermatozoa

Histones and histone phosphorylation play vital roles during animal spermatogenesis and spermatozoa maturation. The dynamic distribution of histones H2A and H4 and phosphorylated H2A and H4 at serine 1 (HS1ph) was explored in mammalian and Decapoda germ cells, with a special focus on the distributio...

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Autores principales: Zhang, Zhao-Hui, Mu, Shu-Mei, Guo, Ming-Shen, Wu, Jiang-li, Li, Yan-qin, Zhang, Han, Wang, Ying, Kang, Xian-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848542/
https://www.ncbi.nlm.nih.gov/pubmed/27121047
http://dx.doi.org/10.1038/srep25089
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author Zhang, Zhao-Hui
Mu, Shu-Mei
Guo, Ming-Shen
Wu, Jiang-li
Li, Yan-qin
Zhang, Han
Wang, Ying
Kang, Xian-Jiang
author_facet Zhang, Zhao-Hui
Mu, Shu-Mei
Guo, Ming-Shen
Wu, Jiang-li
Li, Yan-qin
Zhang, Han
Wang, Ying
Kang, Xian-Jiang
author_sort Zhang, Zhao-Hui
collection PubMed
description Histones and histone phosphorylation play vital roles during animal spermatogenesis and spermatozoa maturation. The dynamic distribution of histones H2A and H4 and phosphorylated H2A and H4 at serine 1 (HS1ph) was explored in mammalian and Decapoda germ cells, with a special focus on the distribution of H2A, H4 and HS1ph between mouse condensed spermatozoa chromatin and crab non-condensed spermatozoa chromatin. The distribution of histone marks was also analysed in mature spermatozoa with different chromatin structures. Histone H2A and H4 marks were closely associated with the relatively loose chromatin structure in crab spermatozoa. The significant decrease in the HS1ph signal during spermatogenesis suggests that eliminating most of these epigenetic marks in the nucleusis closely associated with spermatozoa maturity.
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spelling pubmed-48485422016-05-05 Dynamics of histone H2A, H4 and HS1ph during spermatogenesis with a focus on chromatin condensation and maturity of spermatozoa Zhang, Zhao-Hui Mu, Shu-Mei Guo, Ming-Shen Wu, Jiang-li Li, Yan-qin Zhang, Han Wang, Ying Kang, Xian-Jiang Sci Rep Article Histones and histone phosphorylation play vital roles during animal spermatogenesis and spermatozoa maturation. The dynamic distribution of histones H2A and H4 and phosphorylated H2A and H4 at serine 1 (HS1ph) was explored in mammalian and Decapoda germ cells, with a special focus on the distribution of H2A, H4 and HS1ph between mouse condensed spermatozoa chromatin and crab non-condensed spermatozoa chromatin. The distribution of histone marks was also analysed in mature spermatozoa with different chromatin structures. Histone H2A and H4 marks were closely associated with the relatively loose chromatin structure in crab spermatozoa. The significant decrease in the HS1ph signal during spermatogenesis suggests that eliminating most of these epigenetic marks in the nucleusis closely associated with spermatozoa maturity. Nature Publishing Group 2016-04-28 /pmc/articles/PMC4848542/ /pubmed/27121047 http://dx.doi.org/10.1038/srep25089 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhang, Zhao-Hui
Mu, Shu-Mei
Guo, Ming-Shen
Wu, Jiang-li
Li, Yan-qin
Zhang, Han
Wang, Ying
Kang, Xian-Jiang
Dynamics of histone H2A, H4 and HS1ph during spermatogenesis with a focus on chromatin condensation and maturity of spermatozoa
title Dynamics of histone H2A, H4 and HS1ph during spermatogenesis with a focus on chromatin condensation and maturity of spermatozoa
title_full Dynamics of histone H2A, H4 and HS1ph during spermatogenesis with a focus on chromatin condensation and maturity of spermatozoa
title_fullStr Dynamics of histone H2A, H4 and HS1ph during spermatogenesis with a focus on chromatin condensation and maturity of spermatozoa
title_full_unstemmed Dynamics of histone H2A, H4 and HS1ph during spermatogenesis with a focus on chromatin condensation and maturity of spermatozoa
title_short Dynamics of histone H2A, H4 and HS1ph during spermatogenesis with a focus on chromatin condensation and maturity of spermatozoa
title_sort dynamics of histone h2a, h4 and hs1ph during spermatogenesis with a focus on chromatin condensation and maturity of spermatozoa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848542/
https://www.ncbi.nlm.nih.gov/pubmed/27121047
http://dx.doi.org/10.1038/srep25089
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