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Enterovirus Control of Translation and RNA Granule Stress Responses
Enteroviruses such as poliovirus (PV) and coxsackievirus B3 (CVB3) have evolved several parallel strategies to regulate cellular gene expression and stress responses to ensure efficient expression of the viral genome. Enteroviruses utilize their encoded proteinases to take over the cellular translat...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848588/ https://www.ncbi.nlm.nih.gov/pubmed/27043612 http://dx.doi.org/10.3390/v8040093 |
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author | Lloyd, Richard E. |
author_facet | Lloyd, Richard E. |
author_sort | Lloyd, Richard E. |
collection | PubMed |
description | Enteroviruses such as poliovirus (PV) and coxsackievirus B3 (CVB3) have evolved several parallel strategies to regulate cellular gene expression and stress responses to ensure efficient expression of the viral genome. Enteroviruses utilize their encoded proteinases to take over the cellular translation apparatus and direct ribosomes to viral mRNAs. In addition, viral proteinases are used to control and repress the two main types of cytoplasmic RNA granules, stress granules (SGs) and processing bodies (P-bodies, PBs), which are stress-responsive dynamic structures involved in repression of gene expression. This review discusses these processes and the current understanding of the underlying mechanisms with respect to enterovirus infections. In addition, the review discusses accumulating data suggesting linkage exists between RNA granule formation and innate immune sensing and activation. |
format | Online Article Text |
id | pubmed-4848588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-48485882016-05-04 Enterovirus Control of Translation and RNA Granule Stress Responses Lloyd, Richard E. Viruses Review Enteroviruses such as poliovirus (PV) and coxsackievirus B3 (CVB3) have evolved several parallel strategies to regulate cellular gene expression and stress responses to ensure efficient expression of the viral genome. Enteroviruses utilize their encoded proteinases to take over the cellular translation apparatus and direct ribosomes to viral mRNAs. In addition, viral proteinases are used to control and repress the two main types of cytoplasmic RNA granules, stress granules (SGs) and processing bodies (P-bodies, PBs), which are stress-responsive dynamic structures involved in repression of gene expression. This review discusses these processes and the current understanding of the underlying mechanisms with respect to enterovirus infections. In addition, the review discusses accumulating data suggesting linkage exists between RNA granule formation and innate immune sensing and activation. MDPI 2016-03-30 /pmc/articles/PMC4848588/ /pubmed/27043612 http://dx.doi.org/10.3390/v8040093 Text en © 2016 by the author; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lloyd, Richard E. Enterovirus Control of Translation and RNA Granule Stress Responses |
title | Enterovirus Control of Translation and RNA Granule Stress Responses |
title_full | Enterovirus Control of Translation and RNA Granule Stress Responses |
title_fullStr | Enterovirus Control of Translation and RNA Granule Stress Responses |
title_full_unstemmed | Enterovirus Control of Translation and RNA Granule Stress Responses |
title_short | Enterovirus Control of Translation and RNA Granule Stress Responses |
title_sort | enterovirus control of translation and rna granule stress responses |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848588/ https://www.ncbi.nlm.nih.gov/pubmed/27043612 http://dx.doi.org/10.3390/v8040093 |
work_keys_str_mv | AT lloydricharde enteroviruscontroloftranslationandrnagranulestressresponses |