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Enterovirus Control of Translation and RNA Granule Stress Responses

Enteroviruses such as poliovirus (PV) and coxsackievirus B3 (CVB3) have evolved several parallel strategies to regulate cellular gene expression and stress responses to ensure efficient expression of the viral genome. Enteroviruses utilize their encoded proteinases to take over the cellular translat...

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Autor principal: Lloyd, Richard E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848588/
https://www.ncbi.nlm.nih.gov/pubmed/27043612
http://dx.doi.org/10.3390/v8040093
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author Lloyd, Richard E.
author_facet Lloyd, Richard E.
author_sort Lloyd, Richard E.
collection PubMed
description Enteroviruses such as poliovirus (PV) and coxsackievirus B3 (CVB3) have evolved several parallel strategies to regulate cellular gene expression and stress responses to ensure efficient expression of the viral genome. Enteroviruses utilize their encoded proteinases to take over the cellular translation apparatus and direct ribosomes to viral mRNAs. In addition, viral proteinases are used to control and repress the two main types of cytoplasmic RNA granules, stress granules (SGs) and processing bodies (P-bodies, PBs), which are stress-responsive dynamic structures involved in repression of gene expression. This review discusses these processes and the current understanding of the underlying mechanisms with respect to enterovirus infections. In addition, the review discusses accumulating data suggesting linkage exists between RNA granule formation and innate immune sensing and activation.
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spelling pubmed-48485882016-05-04 Enterovirus Control of Translation and RNA Granule Stress Responses Lloyd, Richard E. Viruses Review Enteroviruses such as poliovirus (PV) and coxsackievirus B3 (CVB3) have evolved several parallel strategies to regulate cellular gene expression and stress responses to ensure efficient expression of the viral genome. Enteroviruses utilize their encoded proteinases to take over the cellular translation apparatus and direct ribosomes to viral mRNAs. In addition, viral proteinases are used to control and repress the two main types of cytoplasmic RNA granules, stress granules (SGs) and processing bodies (P-bodies, PBs), which are stress-responsive dynamic structures involved in repression of gene expression. This review discusses these processes and the current understanding of the underlying mechanisms with respect to enterovirus infections. In addition, the review discusses accumulating data suggesting linkage exists between RNA granule formation and innate immune sensing and activation. MDPI 2016-03-30 /pmc/articles/PMC4848588/ /pubmed/27043612 http://dx.doi.org/10.3390/v8040093 Text en © 2016 by the author; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lloyd, Richard E.
Enterovirus Control of Translation and RNA Granule Stress Responses
title Enterovirus Control of Translation and RNA Granule Stress Responses
title_full Enterovirus Control of Translation and RNA Granule Stress Responses
title_fullStr Enterovirus Control of Translation and RNA Granule Stress Responses
title_full_unstemmed Enterovirus Control of Translation and RNA Granule Stress Responses
title_short Enterovirus Control of Translation and RNA Granule Stress Responses
title_sort enterovirus control of translation and rna granule stress responses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848588/
https://www.ncbi.nlm.nih.gov/pubmed/27043612
http://dx.doi.org/10.3390/v8040093
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