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Role of time delay on intracellular calcium dynamics driven by non-Gaussian noises
Effect of time delay (τ) on intracellular calcium dynamics with non-Gaussian noises in transmission processes of intracellular Ca(2+) is studied by means of second-order stochastic Runge-Kutta type algorithm. By simulating and analyzing time series, normalized autocorrelation function, and character...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848611/ https://www.ncbi.nlm.nih.gov/pubmed/27121687 http://dx.doi.org/10.1038/srep25067 |
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author | Duan, Wei-Long Zeng, Chunhua |
author_facet | Duan, Wei-Long Zeng, Chunhua |
author_sort | Duan, Wei-Long |
collection | PubMed |
description | Effect of time delay (τ) on intracellular calcium dynamics with non-Gaussian noises in transmission processes of intracellular Ca(2+) is studied by means of second-order stochastic Runge-Kutta type algorithm. By simulating and analyzing time series, normalized autocorrelation function, and characteristic correlation time of cytosolic and calcium store’s Ca(2+) concentration, the results exhibit: (i) intracellular calcium dynamics’s time coherence disappears and stability strengthens as τ → 0.1s; (ii) for the case of τ < 0.1s, the normalized autocorrelation functions of cytosolic and calcium store’s Ca(2+) concentration show damped motion when τ is very short, but they trend to a level line as τ → 0.1s, and for the case of τ > 0.1s, they show different variation as τ increases, the former changes from underdamped motion to a level line, but the latter changes from damped motion to underdamped motion; and (iii) at the moderate value of time delay, reverse resonance occurs both in cytosol and calcium store. |
format | Online Article Text |
id | pubmed-4848611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-48486112016-05-05 Role of time delay on intracellular calcium dynamics driven by non-Gaussian noises Duan, Wei-Long Zeng, Chunhua Sci Rep Article Effect of time delay (τ) on intracellular calcium dynamics with non-Gaussian noises in transmission processes of intracellular Ca(2+) is studied by means of second-order stochastic Runge-Kutta type algorithm. By simulating and analyzing time series, normalized autocorrelation function, and characteristic correlation time of cytosolic and calcium store’s Ca(2+) concentration, the results exhibit: (i) intracellular calcium dynamics’s time coherence disappears and stability strengthens as τ → 0.1s; (ii) for the case of τ < 0.1s, the normalized autocorrelation functions of cytosolic and calcium store’s Ca(2+) concentration show damped motion when τ is very short, but they trend to a level line as τ → 0.1s, and for the case of τ > 0.1s, they show different variation as τ increases, the former changes from underdamped motion to a level line, but the latter changes from damped motion to underdamped motion; and (iii) at the moderate value of time delay, reverse resonance occurs both in cytosol and calcium store. Nature Publishing Group 2016-04-28 /pmc/articles/PMC4848611/ /pubmed/27121687 http://dx.doi.org/10.1038/srep25067 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Duan, Wei-Long Zeng, Chunhua Role of time delay on intracellular calcium dynamics driven by non-Gaussian noises |
title | Role of time delay on intracellular calcium dynamics driven by non-Gaussian noises |
title_full | Role of time delay on intracellular calcium dynamics driven by non-Gaussian noises |
title_fullStr | Role of time delay on intracellular calcium dynamics driven by non-Gaussian noises |
title_full_unstemmed | Role of time delay on intracellular calcium dynamics driven by non-Gaussian noises |
title_short | Role of time delay on intracellular calcium dynamics driven by non-Gaussian noises |
title_sort | role of time delay on intracellular calcium dynamics driven by non-gaussian noises |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848611/ https://www.ncbi.nlm.nih.gov/pubmed/27121687 http://dx.doi.org/10.1038/srep25067 |
work_keys_str_mv | AT duanweilong roleoftimedelayonintracellularcalciumdynamicsdrivenbynongaussiannoises AT zengchunhua roleoftimedelayonintracellularcalciumdynamicsdrivenbynongaussiannoises |