Structural Characterization of Humanized Nanobodies with Neutralizing Activity against the Bordetella pertussis CyaA-Hemolysin: Implications for a Potential Epitope of Toxin-Protective Antigen

Previously, the 126-kDa CyaA-hemolysin (CyaA-Hly) fragment cloned from Bordetella pertussis—the causative agent of whooping cough—and functionally expressed in Escherichia coli was revealed as a key determinant for CyaA-mediated hemolysis against target erythrocytes. Here, phagemid-transfected E. co...

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Detalles Bibliográficos
Autores principales: Malik, Aijaz Ahmad, Imtong, Chompounoot, Sookrung, Nitat, Katzenmeier, Gerd, Chaicumpa, Wanpen, Angsuthanasombat, Chanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848625/
https://www.ncbi.nlm.nih.gov/pubmed/27043627
http://dx.doi.org/10.3390/toxins8040099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848625/
https://www.ncbi.nlm.nih.gov/pubmed/27043627
http://dx.doi.org/10.3390/toxins8040099

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