Cargando…

Low Prevalence of Iron and Vitamin A Deficiency among Cambodian Women of Reproductive Age

Nearly half of women of reproductive age (WRA) in Cambodia are anemic. To guide interventions, national data on nutritional causes of anemia, including iron deficiency and vitamin A deficiency, are needed. In 2012, a national household survey in WRA on antibodies to routine vaccine-preventable disea...

Descripción completa

Detalles Bibliográficos
Autores principales: Wieringa, Frank T., Sophonneary, Prak, Whitney, Sophie, Mao, Bunsoth, Berger, Jacques, Conkle, Joel, Dijkhuizen, Marjoleine A., Laillou, Arnaud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848666/
https://www.ncbi.nlm.nih.gov/pubmed/27043624
http://dx.doi.org/10.3390/nu8040197
_version_ 1782429392285204480
author Wieringa, Frank T.
Sophonneary, Prak
Whitney, Sophie
Mao, Bunsoth
Berger, Jacques
Conkle, Joel
Dijkhuizen, Marjoleine A.
Laillou, Arnaud
author_facet Wieringa, Frank T.
Sophonneary, Prak
Whitney, Sophie
Mao, Bunsoth
Berger, Jacques
Conkle, Joel
Dijkhuizen, Marjoleine A.
Laillou, Arnaud
author_sort Wieringa, Frank T.
collection PubMed
description Nearly half of women of reproductive age (WRA) in Cambodia are anemic. To guide interventions, national data on nutritional causes of anemia, including iron deficiency and vitamin A deficiency, are needed. In 2012, a national household survey in WRA on antibodies to routine vaccine-preventable disease immunity was performed. We used serum samples from this survey to estimate the prevalence of iron and vitamin A deficiency in 2112 Cambodian WRA, aged 15 to 39 years. Iron deficiency was classified as low or marginal iron stores (ferritin concentrations corrected for inflammation <15 μg/L and <50 μg/L respectively; Fer), iron deficient erythropoiesis (soluble transferrin receptor concentrations >8.3 mg/L; sTfR), or low total body iron (TBI) derived from Fer and sTfR concentrations (<0 mg/kg). Vitamin A status was classified using retinol binding protein (RBP) concentrations corrected for inflammation as deficient (<0.70 μmol/L) or marginal (<1.05 μmol/L. Overall, the prevalence of low iron stores, low TBI and iron deficient erythropoiesis was 8.1%, 5.0% and 9.3% respectively. Almost 40% of the women had marginal iron stores. Iron status was better in women living in urban areas compared to rural areas (p < 0.05 for TBI and sTfR). The prevalence of vitamin A deficiency was <1%. These findings suggest that the contribution of iron and vitamin A deficiency to the high prevalence of anemia in Cambodian WRA may be limited. The etiology of anemia in Cambodia needs to be elucidated further to guide current policies on anemia.
format Online
Article
Text
id pubmed-4848666
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-48486662016-05-04 Low Prevalence of Iron and Vitamin A Deficiency among Cambodian Women of Reproductive Age Wieringa, Frank T. Sophonneary, Prak Whitney, Sophie Mao, Bunsoth Berger, Jacques Conkle, Joel Dijkhuizen, Marjoleine A. Laillou, Arnaud Nutrients Article Nearly half of women of reproductive age (WRA) in Cambodia are anemic. To guide interventions, national data on nutritional causes of anemia, including iron deficiency and vitamin A deficiency, are needed. In 2012, a national household survey in WRA on antibodies to routine vaccine-preventable disease immunity was performed. We used serum samples from this survey to estimate the prevalence of iron and vitamin A deficiency in 2112 Cambodian WRA, aged 15 to 39 years. Iron deficiency was classified as low or marginal iron stores (ferritin concentrations corrected for inflammation <15 μg/L and <50 μg/L respectively; Fer), iron deficient erythropoiesis (soluble transferrin receptor concentrations >8.3 mg/L; sTfR), or low total body iron (TBI) derived from Fer and sTfR concentrations (<0 mg/kg). Vitamin A status was classified using retinol binding protein (RBP) concentrations corrected for inflammation as deficient (<0.70 μmol/L) or marginal (<1.05 μmol/L. Overall, the prevalence of low iron stores, low TBI and iron deficient erythropoiesis was 8.1%, 5.0% and 9.3% respectively. Almost 40% of the women had marginal iron stores. Iron status was better in women living in urban areas compared to rural areas (p < 0.05 for TBI and sTfR). The prevalence of vitamin A deficiency was <1%. These findings suggest that the contribution of iron and vitamin A deficiency to the high prevalence of anemia in Cambodian WRA may be limited. The etiology of anemia in Cambodia needs to be elucidated further to guide current policies on anemia. MDPI 2016-04-01 /pmc/articles/PMC4848666/ /pubmed/27043624 http://dx.doi.org/10.3390/nu8040197 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wieringa, Frank T.
Sophonneary, Prak
Whitney, Sophie
Mao, Bunsoth
Berger, Jacques
Conkle, Joel
Dijkhuizen, Marjoleine A.
Laillou, Arnaud
Low Prevalence of Iron and Vitamin A Deficiency among Cambodian Women of Reproductive Age
title Low Prevalence of Iron and Vitamin A Deficiency among Cambodian Women of Reproductive Age
title_full Low Prevalence of Iron and Vitamin A Deficiency among Cambodian Women of Reproductive Age
title_fullStr Low Prevalence of Iron and Vitamin A Deficiency among Cambodian Women of Reproductive Age
title_full_unstemmed Low Prevalence of Iron and Vitamin A Deficiency among Cambodian Women of Reproductive Age
title_short Low Prevalence of Iron and Vitamin A Deficiency among Cambodian Women of Reproductive Age
title_sort low prevalence of iron and vitamin a deficiency among cambodian women of reproductive age
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848666/
https://www.ncbi.nlm.nih.gov/pubmed/27043624
http://dx.doi.org/10.3390/nu8040197
work_keys_str_mv AT wieringafrankt lowprevalenceofironandvitaminadeficiencyamongcambodianwomenofreproductiveage
AT sophonnearyprak lowprevalenceofironandvitaminadeficiencyamongcambodianwomenofreproductiveage
AT whitneysophie lowprevalenceofironandvitaminadeficiencyamongcambodianwomenofreproductiveage
AT maobunsoth lowprevalenceofironandvitaminadeficiencyamongcambodianwomenofreproductiveage
AT bergerjacques lowprevalenceofironandvitaminadeficiencyamongcambodianwomenofreproductiveage
AT conklejoel lowprevalenceofironandvitaminadeficiencyamongcambodianwomenofreproductiveage
AT dijkhuizenmarjoleinea lowprevalenceofironandvitaminadeficiencyamongcambodianwomenofreproductiveage
AT laillouarnaud lowprevalenceofironandvitaminadeficiencyamongcambodianwomenofreproductiveage