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The Potential of an in Vitro Digestion Method for Predicting Glycemic Response of Foods and Meals

Increased interest in glycemic response derives from its linkage with chronic diseases, including obesity and type 2 diabetes. Our objective was to develop an in vitro method that predicts glycemic response. We proposed a simulated gastrointestinal digestion protocol that uses the concentration of d...

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Detalles Bibliográficos
Autores principales: Argyri, Konstantina, Athanasatou, Adelais, Bouga, Maria, Kapsokefalou, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848678/
http://dx.doi.org/10.3390/nu8040209
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author Argyri, Konstantina
Athanasatou, Adelais
Bouga, Maria
Kapsokefalou, Maria
author_facet Argyri, Konstantina
Athanasatou, Adelais
Bouga, Maria
Kapsokefalou, Maria
author_sort Argyri, Konstantina
collection PubMed
description Increased interest in glycemic response derives from its linkage with chronic diseases, including obesity and type 2 diabetes. Our objective was to develop an in vitro method that predicts glycemic response. We proposed a simulated gastrointestinal digestion protocol that uses the concentration of dialyzable glucose (glucose in the soluble low molecular weight fraction of digests) as an index for the prediction of glycemic response. For protocol evaluation, dialyzable glucose from 30 foods or meals digested in vitro were compared with published values for their glycemic index (GI) (nine foods), glycemic load (GL) (16 foods) and glycemic response (14 meals). The correlations were significant when comparing dialyzable glucose with GL (Spearman’s rho = 0.953, p < 0.001), GI (Spearman’s rho = 0.800, p = 0.010) and glycemic response (Spearman’s rho = 0.736, p = 0.003). These results demonstrate that despite limitations associated with in vitro approaches, the proposed protocol may be a useful tool for predicting glycemic response of foods or meals.
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spelling pubmed-48486782016-05-04 The Potential of an in Vitro Digestion Method for Predicting Glycemic Response of Foods and Meals Argyri, Konstantina Athanasatou, Adelais Bouga, Maria Kapsokefalou, Maria Nutrients Article Increased interest in glycemic response derives from its linkage with chronic diseases, including obesity and type 2 diabetes. Our objective was to develop an in vitro method that predicts glycemic response. We proposed a simulated gastrointestinal digestion protocol that uses the concentration of dialyzable glucose (glucose in the soluble low molecular weight fraction of digests) as an index for the prediction of glycemic response. For protocol evaluation, dialyzable glucose from 30 foods or meals digested in vitro were compared with published values for their glycemic index (GI) (nine foods), glycemic load (GL) (16 foods) and glycemic response (14 meals). The correlations were significant when comparing dialyzable glucose with GL (Spearman’s rho = 0.953, p < 0.001), GI (Spearman’s rho = 0.800, p = 0.010) and glycemic response (Spearman’s rho = 0.736, p = 0.003). These results demonstrate that despite limitations associated with in vitro approaches, the proposed protocol may be a useful tool for predicting glycemic response of foods or meals. MDPI 2016-04-08 /pmc/articles/PMC4848678/ http://dx.doi.org/10.3390/nu8040209 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Argyri, Konstantina
Athanasatou, Adelais
Bouga, Maria
Kapsokefalou, Maria
The Potential of an in Vitro Digestion Method for Predicting Glycemic Response of Foods and Meals
title The Potential of an in Vitro Digestion Method for Predicting Glycemic Response of Foods and Meals
title_full The Potential of an in Vitro Digestion Method for Predicting Glycemic Response of Foods and Meals
title_fullStr The Potential of an in Vitro Digestion Method for Predicting Glycemic Response of Foods and Meals
title_full_unstemmed The Potential of an in Vitro Digestion Method for Predicting Glycemic Response of Foods and Meals
title_short The Potential of an in Vitro Digestion Method for Predicting Glycemic Response of Foods and Meals
title_sort potential of an in vitro digestion method for predicting glycemic response of foods and meals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848678/
http://dx.doi.org/10.3390/nu8040209
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