Pooling across cells to normalize single-cell RNA sequencing data with many zero counts

Normalization of single-cell RNA sequencing data is necessary to eliminate cell-specific biases prior to downstream analyses. However, this is not straightforward for noisy single-cell data where many counts are zero. We present a novel approach where expression values are summed across pools of cel...

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Detalles Bibliográficos
Autores principales: L. Lun, Aaron T., Bach, Karsten, Marioni, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848819/
https://www.ncbi.nlm.nih.gov/pubmed/27122128
http://dx.doi.org/10.1186/s13059-016-0947-7

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